喜炎平注射液辅助阿奇霉素治疗儿童衣原体肺炎疗效观察  

Efficacy of Xiyanping injection in assisting the treatment with azithromycin for chlamydia pneumonia in children

作　　者：潘凤琪[1] 徐浩[1] 

机构地区：[1]沈阳医学院附属中心医院儿科,沈阳110023

出　　处：《中国中西医结合儿科学》2017年第4期298-300,共3页Chinese Pediatrics of Integrated Traditional and Western Medicine

摘　　要：目的观察喜炎平注射液辅助治疗儿童肺炎衣原体肺炎的临床疗效。方法选择2015年3月至2016年9月沈阳医学院附属中心医院儿科门诊收治的肺炎衣原体肺炎患儿89例为研究对象。随机分为观察组45例和对照组44例。对照组常规使用阿奇霉素静脉滴注3d停4d,为1个疗程,连续使用2个疗程。观察组在对照组治疗基础上给予喜炎平注射液0.2mL/(kg·d)静脉滴注10d。观察两组退热时间、咳嗽治疗效果、阿奇霉素副反应和不良反应。结果两组因没有完成治疗方案,依从性差,失随访脱落8例,最终完成治疗方案和随访的为81例,其中对照组39例,观察组42例。观察组治疗后第3、7、14天咳嗽治疗有效率分别为59.5%(25/42)、73.8%(31/42)、90.5%(38/42),高于对照组20.5%(8/39)、41.0%(16/39)、66.7%(26/39),差异有统计学意义(P<0.05)。观察组退热时间为(3.28±1.52)d,显著低于对照组(4.89±1.46)d,差异有统计学意义(P<0.05)。观察组阿奇霉素副反应发生率为9.5%(4/42),显著低于对照组28.2%(11/39),差异有统计学意义(P<0.05)。观察组患儿在用药前后血尿常规、肝功能、心肌酶谱均无异常变化,无过敏反应病例。结论喜炎平注射液辅助治疗儿童肺炎衣原体肺炎,可较快改善患儿发热和咳嗽等症状,减少阿奇霉素对胃肠道刺激副反应的发生率。Objective To observe the clinical efficacy of Xiyanping injection in assisting the treatment for chlamydia pneumonia in children. Methods A total of 89 children with chlamydia pneumonia were in-cluded as the subjects and were randomly assigned to observation group（45 children） and control group（44 children）. Children in both groups received intravenous infusion of azithromycin for 3 days, followed by a 4- day stop as a course？ for two consecutive courses. Children in the observation group were also given Xiyan-ping injection 0. 2 mL/（kg· d） via intravenous infusion for 10 days. The fever clearance time, effect on cough and side effects were observed between the two groups. Results There were 8 cases whose follow-up was lost because of bad compliance, so finally 81 children completed the treatment plan and follow-up in the two groups, 39 in the control group and 42 in the observation group. In the observation group, fever process was （3. 28 ±1. 52）days. The effective rate in treating cough was 59. 5%（25/42） , 73. 8% （31/42） and 90. 5%（38/42） at 3,7 and 14 days of treatment,respectively. The incidence of side effects of azithro-mycin was 9. 5 % （4/42）. In the control group, fever process was （4. 89 ± 1. 46） days. The effective rate in treating cough was 20. 5% （8/39） , 41. 0% （16/39） and 66. 7% （26/39） at 3 , 7 and 14 days of treatment, re-spectively. The incidence of side effects of azithromycin was 28. 2% （11/39）. Significant differences were shown between the two groups（P〈0 . 05）. Before and after treatment, there was no abnormal change in routine blood and urine test, liver function or myocardial enzymes. Conclusion Xiyanping injection in adju-vant treatment of chlamydia pneumonia in children can rapidly relieve fever and cough, and reduce the incidence of side effects of gastrointestinal irritation caused by azithromycin.

关 键 词：肺炎衣原体肺炎 喜炎平注射液 阿奇霉素 儿童 

分 类 号：R725.6[医药卫生—儿科]