吸烟对40岁以上人群的肺功能的影响  

Effects of cigarette smoking status on lung function in Chinese people 40 years of age or over

作　　者：彭欢欢[1] 刘莎[1] 陈璐[1] 李晓尘[1] 陈淑云[1] 赵东兴[1] 李成龙[1] 郑锦镇 叶秀琴[1] 唐龙辉 洪玮[1] 冉丕鑫[1] 周玉民[1] 

机构地区：[1]广州医科大学附属第一医院呼吸内科国家呼吸疾病临床研究中心呼吸疾病国家重点实验室广州呼吸疾病研究所,510000

出　　处：《国际呼吸杂志》2017年第14期1073-1077,共5页International Journal of Respiration

摘　　要：【摘要】目的观察吸烟对40岁以上人群的肺功能的影响。方法本研究前瞻性调查了2682例居民的吸烟状况、规律合并用药情况、性别、年龄、身高、体质量等资料，并进行了肺通气功能检测。结果随访时间2年。2290例（85．4％）得到了有效随访，其中1197例（52．3％）从不吸烟，467例（20．4％）曾经吸烟，626例（27．3％）现吸烟。三组人群的年龄、性别、BMI、肺功能、cOPD患者例数及合并用药差异均有统计学意义。随访结果显示，肺功能FEV1、FEV1％pred、FVC、FEV1／FVC均逐年下降。经调整上述差异性变量（年龄、性别、BMI、COPD患者例数、合并用药及基线肺功能），曾吸烟组肺功能FEV1（P=0．030）、FEV1％pred（P=0．011）和FEV1／FVC（P〈0．001）较从不吸烟组显著下降。现吸烟组FEV1／FVC较从不吸烟组下降快。结论从不吸烟居民肺功能下降最慢，提倡不吸烟或尽可能早期戒烟。Objective To observe the effect of smoking status on lung function in Chinese people 40 years of age by a 2-year longitudinal follow-up. Methods This study prospectively investigated 2 682 cases of pulmonary ventilation function, smoking status, regularity of residents drug combination and gender, age, height, weight and other information, observation time for two years, 2 290 people （85.4%） complete the follow-up study. Results Of the 2 290 people, 1 197 people （52.3%） are never-smokers, 467 people （20.4%） are ex-smokers, 626 people （27.3%） are current smokers. There were statistically significant differences in the number of age, sex, BMI, tung function COPD and combination therapy among the three groups. After 2 years of follow-up, results show that the lung function FEV1, FEV1% pred, FVC, FEV1/ FVC showed decreased year by year. After adjusted the difference variables, It showed that, to compared with never smokers, ex-smokers significantly reduced lung function FEV1, FEV1%pred and FEV1/ FVC, P values were 0. 030, 0. 011 and 〈0. 001, current smokers significantly reduced lung function FEV1/FVC. Conclusions Never-smokers have the slowest decline in lung function, We advocate non smoking or smoking as early as possible.

关 键 词：吸烟 肺功能 慢性阻塞性肺疾病 

分 类 号：R563.9[医药卫生—呼吸系统]