慢性乙型肝炎患者血清IL-33及其可溶性受体ST2水平变化及其临床意义  

Value of serum IL-33 and its soluble receptor ST2 in patients with chronic hepatitis B

作　　者：王敬先[1] 黄玉英[1] 李燕萍[1] 刘雪瑶[1] 蒋春艳[1] 

机构地区：[1]潍坊市人民医院产前诊断中心,山东潍坊261041

出　　处：《国际检验医学杂志》2017年第15期2074-2075,共2页International Journal of Laboratory Medicine

摘　　要：目的分析血清白细胞介素(IL)-33及其可溶性受体ST2(sST2)水平的变化对慢性乙型肝炎(CHB)患者的临床意义。方法 2014年1月至2016年10月该院收治的CHB患者65例纳入研究组,同期该院体检健康者60例作为对照组。采用ELISA方法测定IL-33及sST2、丙氨酸氨基转移酶(ALT)水平,并进行比较。结果 CHB患者的IL-33、sST2、ALT水平均明显高于对照组,差异均有统计学意义(t=6.542、7.218、6.324,P<0.05)。ALT水平异常的CHB患者的IL-33和sST2明显高于ALT正常的CHB患者,差异有统计学意义(t=16.328、9.874,P<0.05)。结论检测CHB患者的IL-33和sST2可以了解患者免疫状态,为CHB的治疗提供一定的理论参考依据。Objective To explore the clinical value of serum interleukin（IL）-33 and its soluble receptor ST2（sST2）level in patients with chronic hepatitis B.Methods A total of 65 cases with chronic hepatitis B were recruited into study group,meanwhile 60 healthy persons were enrolled in the control group from January 2014 to October 2016 in our hospital.IL-33,sST2 and alanine aminotransferase（ALT）were detected and compared in the two groups.Results The level of IL-33,sST2 and ALT were significant higher than those of the control group（t=6.542,7.218,6.324;P〈0.05）.IL-33 and sST2levels in chronic hepatitis B patients with abnormal ALT level were significant higher than those with normal ALT（t=16.328,9.874,P〈0.05）.Conclusion The detection of IL-33 and sST2in patients with chronic hepatitis B could help to understand the immune status of patients,and provide a theoretical basis for the treatment of chronic hepatitis B.

关 键 词：慢性乙型肝炎 白细胞介素-33 可溶性受体ST2 丙氨酸氨基转移酶 

分 类 号：R512.62[医药卫生—内科学]