哮喘并过敏性鼻炎儿童血清总IgE、外周血嗜酸性粒细胞、过敏原致敏程度与呼出气一氧化氮间的关系  

The correlation between serum total IgE,blood eosinophil,degree of sensitization to allergens and fractional exhaled nitric oxide in children with asthma and allergic rhinitis

作　　者：陈希[1] 郭梓君 郑佩燕[1] 韦妮莉[1] 黄惠敏[1] 孙宝清[1] 

机构地区：[1]广州医科大学附属第一医院/广州呼吸疾病研究所,广州市510120

出　　处：《实用医学杂志》2017年第15期2501-2505,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81572063)

摘　　要：目的分析哮喘合并过敏性鼻炎儿童血清总IgE(total IgE,TIgE)、外周血嗜酸性粒细胞(EOS)、皮肤点刺试验(SPT)致敏程度与呼出气一氧化氮(FeNO)之间的相关性。方法收集哮喘合并过敏性鼻炎的儿童121例,分别进行血清TIgE、外周血EOS和Fe NO检测,以及14种常见过敏原的皮肤点刺试验。结果 75.2%的患儿对2种或以上过敏原致敏。多过敏原致敏的患儿TIgE水平比单致敏的患儿高(P<0.05)。TIgE水平与SPT致敏过敏原数量呈正相关(P<0.05);FeNO水平与TIgE水平和EOS%也有一定的相关性(P<0.05)。屋尘螨SPT结果为2或3级时,其TIgE水平相对0或1级显著增高(P<0.05)。结论 SPT过敏原致敏程度、血清TIgE、外周血EOS和FeNO之间相互联系、相互补充,可以为呼吸道过敏性疾病的临床诊治提供重要的参考。Objective To analyze the correlation among serum total IgE(TIgE),blood eosinophil(EOS)counts,the degree of sensitization for skin prick test(SPT),and fractional exhaled nitric oxide(Fe NO)in children with asthma and allergic rhinitis.Methods We collected 121 children with asthma and allergic rhinitis andtheir serum TIgE,blood EOS,FeNO,and SPT for 14 common allergens.Results There were 75.2% patients sensitizing to at least two allergens.TIgE levels in poly-sensitized subjects were higher than that of mono-sensitized subjects(P<0.05)The number of SPT sensitized allergens was positively correlated with the TIg E levels(P<0.05)FeNO levels were correlated with TIg E levels and EOS percentage(P<0.05).TIg E levels in subjects with class 2 or 3 in SPT for house dust mite increased significantly,compared with class 0 or 1.ConclusionThere were some correlations among the four detections,providing important reference for clinical diagnosis and treatment of respiratory allergic disease

关 键 词：儿童 哮喘合并过敏性鼻炎 血清TIgE 外周血嗜酸性粒细胞 皮肤点刺试验 呼出气一氧化氮 

分 类 号：R725.6[医药卫生—儿科]