左卡尼汀联合血液透析对尿毒症性周围神经病变患者神经传导速度及生活质量的影响  

Study on the effects of L-carnitine combined with hemodialysis on nerve conduction velocity and quality of life in patients with uremic peripheral neuropathy

作　　者：黄爱洁[1] 

机构地区：[1]辽宁中医药大学附属第四医院血液透析科,辽宁沈阳110101

出　　处：《中国生化药物杂志》2017年第8期100-101,105,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨左卡尼汀联合血液透析对尿毒症性周围神经病变患者神经传导速度及生活质量的影响。方法 选取71例尿毒症性周围神经病变患者,按照随机数字表法分组,对照组35例予以血液透析治疗,观察组36例予以血液透析联合左卡尼汀治疗。对比2组胫神经、腓总神经、正中神经的感觉神经传导速度,并统计临床疗效及生活质量（QOL）评分。结果 观察组治疗8周后神经传导速度较对照组高,差异显著（P〈0.05）;观察组治疗总有效率为88.89%（32/36）,高于对照组68.57%（24/35）,差异显著（P〈0.05）;治疗8周后2组QOL评分比较,观察组较高,差异显著（P〈0.05）。结论 对尿毒症性周围神经病变患者给予左卡尼汀、血液透析联合治疗,疗效较好,可提高神经传导速度及生活质量。Objective To investigate the effect of levocarnitine combined with hemodialysis on nerve conduction velocity and quality of life in patients with uremic peripheral neuropathy. Methods A total of 71 patients with uremic peripheral neuropathy were randomly divided into two groups according to the random number table. 35 patients in the control group were treated with hemodialysis. The observation group （36 cases） was treated with hemodialysis and levocarnitine. The sensory nerve conduction velocity in the median nerve, the tibial nerve and peroneal nerve, and clinical efficacy and quality of life （QOL） score in the two groups were compared. Results The rate of nerve conduction in the observation group was significantly higher than those in the control group （P〈0.05）. The total effective rate was 88.89% （32/36） in the observation group, which was higher than 68.57% （24/35） in the control group （P〈0.05）. The scores of QOL in the observation groups was higher than that in the control group （P〈0.05）. Conclusion The combination of levocarnitine and hemodialysis can improve the nerve conduction velocity and quality of life in patients with uremic peripheral neuropathy.

关 键 词：尿毒症性周围神经病变 左卡尼汀 血液透析 神经传导速度 生活质量 

分 类 号：R692.5[医药卫生—泌尿科学]