米诺环素联合阿奇霉素对重症肺炎支原体肺炎患儿血清CRP、D-D及肺功能的影响  

Analyze on the influence of minocycline combined with azithromycin on serum CRP, D-Dimer and lung function in the children with refractory mycoplasma pneumonia

作　　者：李静[1] 王雪艳[1] 王梦娟[1] 王翠[1] 宋国超[1] 

机构地区：[1]天津医科大学第二医院儿科,天津300000

出　　处：《中国生化药物杂志》2017年第8期102-105,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 研究米诺环素联合阿奇霉素对重症肺炎支原体肺炎患儿血清C-反应蛋白（CRP）、D-二聚体（D-D）及肺功能的影响。方法 选取2016年1月-2016年12月天津医科大学第二医院收治的42例重症肺炎支原体肺炎患儿,随机分为观察组和对照组,每组21例。对照组采用阿奇霉素序贯疗法,观察组使用米诺环素联合阿奇霉素完成治疗。比较2组患儿临床疗效,血清CRP、D-D水平,肺功能,临床症状及体征消失时间,不良反应。结果 治疗后,观察组临床总有效率显著高于对照组（P〈0.05）;观察组CRP、D-D水平显著低于对照组;观察组的最高呼气流速峰值（PEE）、第1秒用力呼气量（FEV1）、用力肺活量（FVC）、用力呼气25%流速（MEF25）水平显著高于对照组（P〈0.05）;观察组的X线胸片恢复时间、退热时间、咳嗽消失时间及肺部啰音消失时间显著短于对照组（P〈0.05）。观察组患儿的腹泻、腹痛、恶心、呕吐、胸腔积液、中耳炎、轻度贫血、皮疹不良反应率和对照组比较无显著差异。结论 米诺环素联合阿奇霉素治疗重症肺炎支原体肺炎患儿,能有效降低血清CRP、D-D水平,改善肺功能和临床症状,临床疗效良好。Objective To study the influence of minocycline combined with azithromycin on serum CRP, D-Dimer and lung function in the children with refractory mycoplasma. Methods From April 2015 to August 2016, 42 children with refractory mycoplasma pneumonia were enrolled in the second hospital in Tianjing. The patients were divided into the observation group and the control group according to the order of admission. The control group was treated with azithromycin sequential therapy, the observation group were given minocycline combined with azithromycin to complete the treatment. The levels of serum CRP, D-D, lung function, clinical symptoms and signs, and the adverse effects were observed. Results After treatment, the total effective rate of the observation group was significantly higher than that in the control group （P〈0.05）. The levels of CRP and D-D in the observation group were significantly lower than those in the control group （P〈0.05）. The highest expiratory flow velocity （PEE）, first-second forced expiratory volume （FEV1）, forced vital capacity （FVC） and forced expiratory 25% flow rate （MEF25） in the observation group were significantly higher than those in the control group （P〈0.05）. The time of X-ray recovery time, the time of fever, the time of cough and the disappearance of lung rales were significantly shorter than those in the control group （P〈0.05）. Compared with the control group, there were no significant differences in diarrhea, abdominal pain, nausea, vomiting, pleural effusion, otitis media, mild anemia and rash adverse reaction rate in the observation group. Conclusion Minocycline combined with azithromycin in the treatment of severe Mycoplasma pneumoniae pneumonia can effectively reduce serum levels of CRP and D-D, improve pulmonary function and clinical symptoms, and have good clinical efficacy.

关 键 词：米诺环素 阿奇霉素 支原体肺炎 肺功能 

分 类 号：R725.6[医药卫生—儿科]