心理干预联合马来酸依那普利片对维持性血液透析患者血清微炎症指标和营养指标的影响  

Effect of serum micro inflammatory and nutritional indexes of psychological intervention combined with enalapril maleate tablets on the treatment of the patients with maintenance hemodialysis

作　　者：范淑芳[1] 徐燕琳[1] 

机构地区：[1]建德市第一人民医院血透室,浙江建德311600

出　　处：《中国生化药物杂志》2017年第8期189-190,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 研究分析心理干预联合马来酸依那普利片对维持性血液透析患者血清微炎症指标和营养指标的影响.方法 选取建德市第一人民医院2015年2月-2016年8月收治的80例慢性肾衰竭进行维持性血液透析患者为研究对象,随机分为对照组和试验组各40例.对照组与试验组患者均给予马来酸依那普利片治疗,试验组患者同时进行心理干预治疗.比较分析试验组与对照组患者的血清微炎症指标和营养指标变化.结果 试验组hs-CRP、TNF-α水平下降程度明显多于对照组,差异具有统计学意义（P〈0.05）.试验组患者的前白蛋白以及血浆白蛋白水平显著高于对照组组,差异具有统计学意义（P〈0.05）.治疗后,试验组患者的SAS评分为（42.3±5.2）分,SDS评分为（40.1±5.9）分.对照组患者的SAS评分为（60.9±9.2）分,SDS评分为（59.1±7.4）分;试验组患者的抑郁以及焦虑评分显著低于对照组患者,差异具有统计学意义（P〈0.05）.结论 心理干预联合马来酸依那普利片能够显著改善维持性血液透析患者血清微炎症指标,恢复患者营养状态,消除患者负面情绪,具有进一步推广和应用的意义.Objective To investigate and analyze the effect of serum micro inflammatory and nutritional indexes of psychological intervention combined with enalapril maleate tablets on the treatment of the patients with maintenance hemodialysis. Methods 100 patients with chronic renal failure in Jiande the first people＆#39;s hospital from February 2015 to August 2016 were selected as the subjects, and randomly divided into the control group and the experimental group. The control group and the experimental group were given enalapril maleate tablets, at the same time, the experimental group were received psychological intervention. The changes of serum micro inflammation indexes and nutritional indexes in the the two groups were compared and analyzed. Results The HsCRP, TNF alpha levels in the experimental group decreased significantly than those in the control group, the differences had statistical significant （P〈0.05）. The levels of prealbumin and plasma albumin in the experimental group were significantly higher than those in the control group （P〈0.05）. After treatment, the SAS score in the experimental group was （42.3±5.2） points, and the SDS score was （40.1±5.9） points. The SAS score in the control group was （60.9±9.2） points, and the SDS score was （59.1±7.4） points. The scores of depression and anxiety in the experimental group were significantly lower than those in the control group （P〈0.05）. Conclusion Psychological intervention combined with enalapril maleate tablets used in maintenance hemodialysis patients, which can significantly improve patients＆#39; serum inflammation index, restore the nutritional status of patients, eliminate the negative emotion of patients, with further clinical promotion and application significance.

关 键 词：马来酸依那普利片 维持性血液透析 心理干预 微炎症指标 

分 类 号：R459.5[医药卫生—治疗学]