糠酸莫米松鼻喷剂、氯雷他定、健康教育联合治疗小儿变应性鼻炎的临床疗效及对IL-10,IL-17的影响  

Effect of mometasone furoate nasal spray, loratadine and health education on children with allergic rhinitis and its effect on IL-10 and IL-17

作　　者：孟康康[1] 应超[1] 

机构地区：[1]义乌市中心医院儿科,浙江义乌322000

出　　处：《中国生化药物杂志》2017年第8期218-219,221,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨糠酸莫米松鼻喷剂、氯雷他定、健康教育联合治疗小儿变应性鼻炎的临床疗效及对IL-10、IL-17的影响。方法 选取2015年1月-2016年12月于义乌市中心医院诊治的变应性鼻炎患儿50例,依不同治疗方式分为对照组与观察组,各25例。对照组用氯雷他定治疗,观察组用糠酸莫米松鼻喷剂＋氯雷他定＋健康教育治疗;详细观察记录2组患儿治疗前后鼻部症状评分情况、IL-10及IL-17水平情况、不良反应发生情况,并将所获相关数据作对比分析。结果 糠酸莫米松鼻喷剂＋氯雷他定＋健康教育（观察组）治疗变应性鼻咽患儿的效果优于单纯氯雷他定（对照组）治疗效果,患儿鼻部症状改善情况、IL-10及IL-17改善情况均优于对照组,差异有统计学意义（P〈0.05）;2组患儿不良反应发生率比较,差异无统计学意义。结论 变应性鼻炎患儿选择糠酸莫米松鼻喷剂＋氯雷他定＋健康教育的治疗效果显著,可有效改善患儿鼻部症状、IL-10及IL-17,并不会增加患儿不良反应发生率,值得临床上广泛应用。Objective To investigate the clinical curative effect of combined treatment of mometasone furoate nasal spray, loratadine, health education on children with allergic rhinitis and effects on IL-10 and IL-17. Methods 50 children with allergic rhinitis in our hospital from January 2015 to December 2016 were selected,and according to the different treatment methods divided into observation group and control group,25 cases in each groups.The control group were treated with loratadine, observation group with mometasone furoate nasal spray of loratadine ＋ ＋ health education treatment; we observed the two groups before and after treatment in children with nasal symptoms score, IL-10 and IL-17 and the incidence of adverse reactions, and the relevant data for comparative analysis. Results Mometasone furoate nasal spray of loratadine ＋ ＋ Health Education （observation group） the effect of treatment of children with allergic nasal is better than loratadine （control group） treatment, symptoms to improve the situation, IL-10 and IL-17 are better than the control group, the difference was statistically significant （P〈0.05）; two groups children with adverse reaction rate comparison, the difference was not statistically significant. Conclusion Children with allergic rhinitis selection of mometasone furoate nasal spray ＋ loratadine ＋ health education treatment effect significantly, can effectively improve the symptoms, IL-10 and IL-17, and will not increase the incidence of adverse reactions, it is worthy of clinical application.

关 键 词：糠酸莫米松 氯雷他定 健康教育 变应性鼻炎 白细胞介素-10 白细胞介素-17 

分 类 号：R725.6[医药卫生—儿科]