洛汀新对急性心肌梗死患者炎症因子、血管内皮功能及心功能的影响  

Effect of Lotensin on inflammatory factors, vascular endothelial function and heart function in patients with acute myocardial infarction

作　　者：贾晓刚[1] 胡圣[1] 曹中南 左国兴 王宽[1] 杜新平[1] 

机构地区：[1]天津市第五中心医院心内科,天津300450

出　　处：《中国生化药物杂志》2017年第8期228-230,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨洛汀新对急性心肌梗死患者炎症因子、血管内皮功能及心功能的影响。方法 选取2015年3月-2016年1月天津市第五中心医院接诊的100例急性心肌梗死患者作为本次研究对象。对照组进行常规治疗,在常规治疗的基础上观察组给予洛汀新治疗,观察2组患者治疗后心功能指标、炎症因子水平、血管内皮功能以及血清NO、内皮素1含量,观察2组疗效。结果 观察组LVESV、LVEDV（156.28±3.29、213.45±6.12）mL优于对照组（162.98±4.16、202.83±7.16）mL,LVEF（48.72±2.13）%高于对照组（40.62±3.29）%（P〈0.05）;观察组HsCRP、IL-6水平（2.66±0.68）mg/L、（4.90±0.92）ng/L均小于对照组（6.35±1.50）mg/L、（9.38±2.01）ng/L（P〈0.05）;观察组FMD（10.37±0.62）%优于对照组（6.16±0.92）%（P〈0.05）;观察组NO、ET-1水平（71.52±13.21）μmol/L、（56.27±7.10）ng/L均优于对照组（60.63±10.57）μmol/L、（69.72±9.50）ng/L（P〈0.05）;观察组总有效率94.00%（47/50）优于对照组62.00%（31/50）（P〈0.05）。结论 洛汀新治疗急性心肌梗死疗效显著,能够降低患者的炎症因子,改善内皮功能,保护心血管。Objective To investigate the effects of Lotensin on inflammatory factors, vascular endothelial function and heart function in patients with acute myocardial infarction. Methods 100 cases with acute myocardial infarction from March 2015 to January 2016 in the fifth central hospital of Tianjin were selected as the research object, which were randomly divided into the control group and the observation group. The control group were given routine treatment, at this basis, the observation group were given Lotensin. After treatment, the cardiac function, the levels of inflammatory factors, the blood vessel endothelial function, the serum NO and endothelin 1 and the therapeutic effect in the two groups were compared. Results LVESV, LVEDV （156.28±3.29、213.45±6.12） mL in the observation group were better than （162.98±4.16、202.83±7.16） mL in the control group （P〈0.05）. LVEF was （48.72± 2.13）% in the observation, which was higher than （40.62±3.29）% in the control group（P〈0.05）. Hs-CRP, IL-6 were （2.66±0.68） mg/L、（4.90±0.92） ng /L in the observation group , which were less than （6.35±1.50） mg/L、（9.38±2.01） ng/L in the control group （P〈0.05）. FMD（10.37±0.62）% in the observation group was bet er than （6.16±0.92）% in the control group （P〈0.05）、 NO, ET-1 level （71.52±13.21） μmol/L、（56.27±7.10） ng/L in the observation group were bet er than （60.63 ±10.57） μmol/L、（69.72±9.50） ng/L in the control group （P〈0.05）. The total effective rate in the observation group was 94.00% （47/50）, which was better than 62.00% （31/50） in the control group （P〈0.05）. Conclusion The effect is significant which Lotensin is used in the treatment of acute cerebral infarction, which can reduce inflammatory factors, improve endothelial function and cardiovascular function.

关 键 词：洛汀新 急性心肌梗死 炎症因子 血管内皮功能 心功能 

分 类 号：R541[医药卫生—心血管疾病]