甲状腺球蛋白及其抗体研究进展  

Research progress on thyroglobulin and its antibody

作　　者：李娜[1] 杨帆[1] 胡蕴[1] 毛晓明[1] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)内分泌科,南京医学硕士研究生210006

出　　处：《医学研究生学报》2017年第8期869-872,共4页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81570710)

摘　　要：甲状腺球蛋白(Tg)基因多态性、人类白细胞抗原(HLA)与Tg以及碘与Tg的相互作用可能参与自身免疫性甲状腺疾病(AITD)的发病,且机体针对Tg产生的自身抗体,即甲状腺球蛋白抗体(Tg Ab),作为AITD重要标志也与AITD发生与发展密切相关,另外,TgAb IgG各亚型表达水平差异在AITD的分型和诊断中也有广泛的应用前景。文章通过对Tg的相关研究,进一步了解AITD的发病机制,并为其诊断及临床治疗提供依据。Tg gene polymorphism,HLA and iodine interaction with Tg may be involved in the pathogenesis of autoimmune thyroid disease. Moreover,thyroglobulin antibody（Tg Ab）,an important symbol of autoimmune thyroid disease,is also closely related to the development of autoimmune thyroid disease. In addition,the differences of Tg Ab Ig G isoforms expression level also have broad application prospects in the classification and diagnosis of autoimmune thyroid disease. By researching on Tg,we review the pathogenesis of autoimmune thyroid disease and provided the evidence for its diagnosis and clinical treatment.

关 键 词：自身免疫性甲状腺疾病 甲状腺球蛋白 甲状腺球蛋白基因 甲状腺球蛋白抗体 

分 类 号：R581[医药卫生—内分泌]