头孢他啶与奥硝唑氯化钠注射液序贯静滴的稳定性考察  

Stability of Ceftazidime and Ormidazole Chloride Sodium Injection with Sequential Intravenous Dripping

作　　者：王纯叶 王婷 李文斌 詹云丽 贾利红 

机构地区：[1]惠州市第一妇幼保健院药剂科,广东惠州516007 [2]惠州市食品药品检验所 [3]惠州市第一妇幼保健院产科

出　　处：《中国药师》2017年第8期1505-1507,共3页China Pharmacist

摘　　要：目的:考察注射用头孢他啶与奥硝唑氯化钠注射液序贯静滴的稳定性。方法:测定两药配伍后的pH,溶液颜色变化,采用紫外分光光度计测定吸收曲线变化及含量变化。结果:头孢他啶奥硝唑混合液质量比为1∶25,1∶50,1∶100时,分别在40,45,48min颜色由微淡黄色变为淡粉红色,随着时间延长混合液颜色逐渐加深。奥硝唑头孢他啶混合液质量比1∶400,1∶800,1∶1 600,3h内混合液无颜色变化。以上两种模拟临床序贯静滴顺序的混合液峰型,含量均无明显变化。结论:头孢他啶与奥硝唑氯化钠注射液序贯静滴时配伍后可能会发生颜色变化。临床药师建议先静滴奥硝唑氯化钠注射液,再序贯静滴头孢他啶。Objective： To investigate the compatible stability of ceftazidime and ormidazole chloride sodium injection with＇ sequen- tim intravenous dripping. Methods ： The contents and the absorption curves of ceftazidime and ormidazole sodium chloride injection in the mixture were determined by UV. The appearance of the solution was observed and the pH value was determined. Resttlts： With the quality ratio of ceftazidimc to ormidazole at 1 ： 25, 1 ： 50 and 1 ： 100, the mixture color changed from light yellow to light pink in 40, 45 and 48 rain, respectively, and gradually deepened with the extension of time. With the quality ratio of ormidazo｜e to ceftazidime mixture at I ： 400, 1 ： 800 and 1 ： 1 600, the color was stable in 3 h. There were no evident changes in the appearance, pH, content and abso/ption curves. Conclusion： The solution containing ormidazole and ceftazidime might have changes in color. Clinical pharma- cist suggests that ormiclazole chloride sodium injection be given intravenously, and then sequentially followed by ceftasidime.

关 键 词：头孢他啶 奥硝唑 配伍 紫外分光光度法 稳定性 

分 类 号：R942[医药卫生—药剂学]