活血化浊法治疗糖尿病肾病的临床研究  

Clinical study of the treatment of diabetic nephropathy with promoting blood circulation for eliminating turbid pathogen method

作　　者：潘洪权[1] 伊娜[2] 

机构地区：[1]广州中医药大学,广州510000 [2]广州中医药大学附属广州中医院内分泌科

出　　处：《现代中医临床》2017年第4期43-45,49,共4页Modern Chinese Clinical Medicine

摘　　要：目的观察活血化浊法对早期糖尿病肾病的临床疗效。方法选取2016年5—11月在广州市中医院内分泌科收治的糖尿病肾病Ⅲ~Ⅳ期患者60例,随机分为治疗、对照组各30例,对照组予基础治疗加培哚普利片,治疗组在对照组基础上再加活血化浊方,2组均治疗30 d,观察比较临床疗效、证候疗效,以及治疗前后尿微量白蛋白(m ALB)/肌酐(Cr)、Cr、尿素氮(BUN)、超敏C反应蛋白(hs CRP)、白介素-6(IL-6)水平变化情况。结果治疗组总有效率(96.67%)优于对照组(73.33%),差异有统计学意义;2组证候积分、mALB/Cr、hsCRP、IL-6水平治疗后较治疗前有所降低,治疗前后差异有统计学意义,且治疗组优于对照组;2组Cr、BUN水平治疗前后改变无统计学意义。结论西药联合活血化浊法可明显改善糖尿病肾病患者临床症状,减少尿蛋白,其机制可能与下调肾脏炎症反应有关。Objective To observe the curative effect of promoting blood circulation for eliminating turbid pathogen method in the treatment of early diabetic nephrology. Methods 60 patients with stage Ⅲ or Ⅳ diabetic nephrology who were enrolled in the endocrinology department, Guangzhou hospital of TCM, from May 2016 to November 2016 were collected. The patients were randomly divided into treatment group and control group, with 30 in each. The control group was given conventional therapy and perindo- pril tablets, while the treatment group was given promoting blood circulation for eliminating turbid patho- gen formula besides the control group. The treatment lasted 30 days, and the curative effect, syndrome effect, as well as the changes of microalbumin, creatinine, urea nitrogen, high-sensitivity C-reactive pro- tein and interleukin-6 before and after treatment were compared. Results The total effective rate of treatment group （96.67%）was superior to the control group（73.33% ）, and the difference was signifi cant. After treatment, the syndrome score, mALB/Cr, hsCRP and IL-6 decreased significantly, and the treatment group was superior to the control group. The changes no statistical difference. Conclusion Western medicine comb nating turbid pathoge ie nephropathy, and of Cr and BUN before-after treatment had ined promoting blood circulation for elimi- n method could significantly improve symptoms and reduce its mechanism may be related to down-regulating the renal urinary protein of diabet- inflammatory response.

关 键 词：活血化浊 糖尿病肾病 炎症 培哚普利 超敏C反应蛋白 白介素-6 

分 类 号：R255.4[医药卫生—中医内科学]