广东地区冠心病患者外周血中eHSP90α的表达水平及意义  

Expression and significance of eHSP90α in peripheral blood of patients with coronary heart disease in Guangdong

作　　者：吕自明[1] 蔡凯[1] 李巧汶[1] 李健洪[1] 

机构地区：[1]广州医科大学附属第六医院胸心五区,广东清远511518

出　　处：《分子影像学杂志》2017年第3期331-334,共4页Journal of Molecular Imaging

基　　金：广东省自然科学基金(2016A030607034)

摘　　要：目的探讨eHSP90α在冠心病发生发展中的作用和意义。方法选取2013年6月~2016年6月在本院住院的广东籍冠心病患者101例及对照组31例,收集病情资料,检测外周血eHSP90α含量。分析外周血eHSP90α含量与冠心病患者病情的关系。结果冠心病患者外周血中eHSP90α水平较对照组升高(P<0.01)。不稳定型冠心病患者外周血eHSP90α含量高于稳定性冠心病患者(92.17±23.63 ng/L vs 15.84±15.83 ng/L,P<0.01),冠心病合并心衰患者外周血eHSP90α含量高于不合并心衰发生的患者(93.04±22.94 ng/L vs 81.49±20.44 ng/L,P<0.05)。冠心病合并IV级、III级心衰患者外周血eHSP90α差异没有统计学意义(P=0.158)。结论血中eHSP90α含量与广东地区冠心病患者病情相关,进一步深入研究也许可作为冠心病病情血学标志。Objective To investigate the effect of secreted Hsp90α （eHSP90α） on the development and progression of coronary heart disease （CHD）. Methods A total of 101 patients with CHD and 31 cases as healthy control group were enrolled in this study from June 2013 to June 2016. The eHSP90 alevels in peripheral blood of all cases were collected. The correlation of eHSP90α levels in peripheral blood with condition of patients with CHD was analyzed. Results The eHSP90α levels in peripheral blood of patients with CHD was significantly higher than that of healthy control group （P〈0.01）. In patients with CHD, eHSP90α levels in peripheral blood in unstable CHD group was significantly higher than that in stable CHD group （P〈0.01）. The eHSP90a levels in peripheral blood in CHD combined with heart failure was significantly higher than that in patients group without heart failure （P〈0.05）. The eHSP90α levels in peripheral blood of CHD patients with grade 1V heart failure had no significant difference with grade III heart failure patients （P=0.158）. Conclusion The eHSP90α levels in peripheral blood are closely related to the condition of CHD in Guangdong. It may be a serological marker of coronary heart disease by further study.

关 键 词：冠心病 eHSP90α 心衰 

分 类 号：R541.4[医药卫生—心血管疾病]