单纯特发性低促性腺激素性性腺功能减退症合并Ⅰ型糖尿病相关机制分析  

Correlation analysis of idiopathic hypogonadotropic hypogonadism with type 1 diabetes

作　　者：于璐[1] 鲁平[1] 阚全娥[1] 

机构地区：[1]河南省人民医院内分泌科,郑州450003

出　　处：《医药论坛杂志》2017年第7期28-30,33,共4页Journal of Medical Forum

摘　　要：目的探讨单纯特发性低促性腺激素性性腺功能减退症合并Ⅰ型糖尿病的发病相关机制。方法分析2011至2016年12月在河南省人民医院内分泌科住院确诊的2例特发性低促性腺激素性性腺功能减退症合并Ⅰ型糖尿病患者的临床资料,并进行详实的文献复习。结果Ⅰ型糖尿病人群由于雌激素、胰岛素抵抗、炎症介质等的影响,有发生性腺功能减退倾向,特发性低促性腺激素性性腺功能减退症人群发生糖尿病的风险增加。结论特发性低促性腺激素性性腺功能减退症与Ⅰ型糖尿病在激素、代谢、基因水平有潜在联系,临床医生要加强对此类病例的认识,并为日后可能开展的对于特发性低促性腺激素性性腺功能减退症的进一步研究积累资料。Objective To disscuss the pathogenesis of idiopathic hypogonadotropic hypogonadism with type 1 diabetes.Methods Analyzed two cases of IHH with type 1 diabetes,which is scarce. Results There is a tendency to hypogonadotropic hypogonadism in the patient of type 1 diabetes. The risk of developing diabetes increase during the patient with hypogonadotropic hypogonadism. Conclusion The hormones,metabolism and gene may participate in the coexistence of idiopathic hypogonadotropic hypogonadism and type 1 diabetes.

关 键 词：特发性低促性腺激素性性腺功能减退症 Ⅰ型糖尿病 机制 

分 类 号：R588[医药卫生—内分泌]