肾上腺素能系统介导的棕色/米色脂肪产热在治疗肥胖中的应用局限性  

Application limitations of sympathetic nerve-mediated thermogenesis of brown/ beige adipose tissue in the treatment of obesity

作　　者：马度芳 姜萍[1] 王永成[1] 李晓[2] 

机构地区：[1]山东中医药大学第一临床医学院,济南250300 [2]山东中医药大学附属医学心内科

出　　处：《中华内分泌代谢杂志》2017年第7期625-628,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目（81102676）

摘　　要：由于激活棕色/米色脂肪产热具有降低体重和改善代谢的作用,这使其成为多种能量代谢性疾病研究的热点.但根据最新研究,通过增加棕色/米色脂肪产热实现减肥和改善代谢仍存在应用问题.人体中,肥胖导致的棕色脂肪功能障碍使其产热能力明显降低.米色脂肪细胞产热明显低于棕色脂肪.因此,若要达到抗肥胖的作用,需要有足够强度的肾上腺素能刺激以提高棕色脂肪产热,诱导足够大体积的白色脂肪转化为米色脂肪.然而,高强度激活肾上腺素能系统可对心血管系统产生不良反应.另外,过度诱导白色脂肪“米色化”可能会破坏脂肪组织整体稳态而加重外周脂质代谢紊乱.因此,解决棕色/米色脂肪在改善机体代谢实际应用中存在的问题应该是又一新的重要研究领域.Studies on promoting thermogenesis of brown and beige adipose tissue have become a hot topic in various metabolic conditions, which based on the conclusions that brown and beige adipose tissue are able to facilitate weight loss and improve metabolic health.However, recent studies showed that there were several problems for the anti-obesity application via promoting brown/beige adipose tissue thermogenesis.In obese individuals, classical brown adipose tissue presents thermogenesis dysfunction.Moreover, the beige adipose tissue has significantly lower thermogenesis capability compared with brown adipose tissue.On such conditions, excessively excited sympathetic innervation is essential to increase energy consumption in obesity via increasing classic brown adipose thermogenesis and inducing white adipose tissue ＆quot;browning＆quot;.However, excessive excited sympathetic nerve results in cardiovascular side effects.Additionally, excessive induction of white adipose tissue ＆quot;browning＆quot; might disrupt the white adipose tissue homeostasis and aggravate the intrinsic metabolic disorders.Therefore, solving these practical application problems of brown/beige adipose tissue is a new research area for improving metabolic disorders.

关 键 词：棕色脂肪 米色脂肪 白色脂肪“米色化” 肥胖 能量代谢 应用局限性 

分 类 号：R589.2[医药卫生—内分泌]