天津市经性传播新发感染HIV-1人群的CD4^+T淋巴细胞基线水平分析  

Baseline CD4^+T cell counts among newly sexual-transmitted HIV cases in Tianjin city of China

作　　者：李龙[1] 宁铁林[1] 郑敏娜[1] 赵璇[1] 朱静瑾 郑钟洁[1] 柳忠泉[1] 程绍辉[1] 

机构地区：[1]天津市疾病预防控制中心性病艾滋病预防控制室,天津300011

出　　处：《中国病毒病杂志》2017年第3期210-213,共4页Chinese Journal of Viral Diseases

基　　金：天津市卫生行业重点攻关项目(14KG119);天津市疾病预防控制中心科技基金项目(CDCKY1602)

摘　　要：目的了解天津市经性传播新发感染HIV-1人群的CD4^+T淋巴细胞基线水平,为制定疾病防控政策和临床医生诊疗提供重要信息。方法通过BED HIV-1捕获酶联免疫技术(BED HIV-l incidence capture enzyme immunoassay,BED-CEIA)将205例经性传播感染HIV-1确证阳性者判断为新发感染,对其CD4^+T淋巴细胞数值进行卡方检验和非参数检验。结果男男性行为人群(men who have sex with men,MSM)和异性传播人群HIV-1感染者中CD4^+T淋巴细胞计数<350个/μl所占比例分别为36.67%(55/150)、27.27%(15/55);CD4^+T淋巴细胞计数<500个/μl所占比例分别为73.33%(110/150)、49.09%(27/55),CD4^+T淋巴细胞中位数M(四分位数间距,IQR)分别为395个/μl(201.75个/μl)、501个/μl(398个/μl)。MSM人群感染者中大部分已进入建议治疗时期,CD4^+T淋巴细胞基线水平低于异性传播人群,差异有统计学意义(P=0.001)。MSM人群中≤25岁、26~35岁、≥36岁3个年龄组感染者的CD4^+T淋巴细胞水平差异无统计学意义(P=0.651)。结论天津市经性传播新发感染HIV-1人群尤其是MSM人群的感染者CD4^+T淋巴细胞基线水平较低,确证感染后应尽快检测CD4^+T淋巴细胞,及时启动抗病毒治疗以便获得更好的治疗效果,同时应制订相应的政策,遏制HIV-1经性途径快速传播。Objective To study the baseline CD4^＋T cell counts among individuals with recently sexual-transmitted HIV-1in Tianjin,China. Methods BED HIV-1incidence capture enzyme immunoassay（BED-CEIA）was applied on HIV-positive individuals to identify sexual-transmitted HIV-1cases.CD4^＋T cell counts of these cases were statistically analyzed. Results CD4^＋T cell counts〈350cells/μl among men who have sex with men（MSM）and heterosexual individuals population accounted for 36.67%（55/150）and 27.27%（15/55）,respectively.CD4^＋T cell counts〈500cells/μl were 73.33%（110/150）,49.09%（27/55）and the median CD4^＋T cell counts were 395cells/μl and 501cells/μl,respectively.Baseline CD4^＋T cell counts in MSM population was significantly lower than that in heterosexual population（P=0.001）.There were no statistical difference in baseline CD4^＋T cell counts of different age groups in MSM population. Conclusions Comparing to heterosexual individuals,sexual-transmitted HIV-1infection in MSM population showed lower baseline CD4^＋T cell counts in Tianjin of China.

关 键 词：人类免疫缺陷病毒 男男性行为人群 CD4^+T淋巴细胞 BED捕获酶联免疫技术 

分 类 号：R512.91[医药卫生—内科学]