复方甘草酸苷片联合地氯雷他定片及重组牛碱性成纤维细胞生长因子凝胶治疗面部激素依赖性皮炎疗效及安全性评价  

Effect and safety of compound glycyrrhizin combined with desloratadine tablet and recombinant bovine basic fibroblast growth factor gel in the treatment of facial steroid-dependent dermatitis

作　　者：王希香 张信江[2] 朱月玲 谢云峰 高国强 刘志梅[3] 

机构地区：[1]洛阳东方医院皮肤科,河南洛阳471003 [2]遵义医学院附属医院皮肤科,贵州遵义563000 [3]遵义医药高等专科学校皮肤性病学教研室,贵州遵义563006

出　　处：《新乡医学院学报》2017年第7期639-643,646,共6页Journal of Xinxiang Medical University

摘　　要：目的评价复方甘草酸苷片联合地氯雷他定片及重组牛碱性成纤维细胞生长因子凝胶治疗面部激素依赖性皮炎的疗效及安全性。方法选择洛阳东方医院2014年3月至2016年3月收治的116例面部激素依赖性皮炎患者并随机分为观察组和对照组,每组58例。2组患者均每晚1次口服地氯雷他定片5 mg,患处薄层涂抹重组牛碱性成纤维细胞生长因子凝胶,早晚各1次,共12周。观察组患者同时口服复方甘草酸苷片50 mg,每日3次,疗程12周。治疗4、8、12周后及停药4周后观察患者面部症状及体征,并进行评分,计算痊愈率、显效率。结果治疗4、8、12周后,观察组患者的痊愈率、有效率均显著高于对照组(P<0.05)。治疗前,2组患者的临床症状体征评分总积分及各项临床症状、体征评分比较差异均无统计学意义(P>0.05)。治疗4、8、12周后,2组患者的临床症状体征评分总积分与治疗前比较均显著降低(P<0.05)。治疗8周后,观察组患者的临床症状体征评分总积分较治疗4周后显著下降(P<0.05);治疗12周后,对照组和观察组患者的临床症状体征评分总积分均较治疗8周后显著下降(P<0.05)。停药后4周,2组患者的临床症状体征评分总积分均较治疗12周后下降(P<0.05)。观察组患者治疗4、8、12周及停药后4周的临床症状体征评分总积分均显著低于对照组(P<0.05)。治疗8、12周后,2组患者色素沉着、表皮萎缩评分与治疗前比较显著降低(P<0.05)。治疗8周后,2组患者红斑、鳞屑、丘疹、脓疱、毛细血管扩张、色素沉着评分与治疗4周后比较显著降低(P<0.05)。治疗12周后,2组患者红斑、鳞屑、丘疹、脓疱、毛细血管扩张评分与治疗8周后比较显著降低(P<0.05);对照组患者色素沉着评分与治疗4周后比较显著降低(P<0.05);观察组患者色素沉着、表皮萎缩评分与治疗4、8周后比较显著降低(P<0.05)。治疗4、8、12周后,观察组患者的红斑�Objective To evaluate the effect and safety of compound glycyrrhizin combined with desloratadine tablet and recombinant bovine basic fibroblast growth factor gel in the treatment of facial steroid-dependent dermatitis. Methods A total of 116 patients with facial hormone-dependent dermatitis were selected from March 2014 to March 2016 in Dongfang Hospital of Luoyang City. The patients were randomly divided into observation group and control group,58 patients in each group.The patients in the two groups were given desloratadine tablet 5 mg orally,once per night; the affected area was coated with recombinant bovine basic fibroblast growth factor gel,once a day for 12 weeks. Based on this,the patients in the observation group were given compound glycyrrhizin tablet 50 mg orally,3 times a day for 12 weeks. The facial symptoms and signs were observed and scored,and the cure rate and excellence rate were calculated at the time points of after 4,8,12 weeks of treatment and 4 weeks after treatment. Results The cure rate and effective rate in the observation group were significantly higher than those in the control group after 4,8 and 12 weeks of treatment（ P〈0. 05）. There was no significant difference in the total score of clinical symptoms and the scores of every clinical symptom and sign between the two groups before treatment（ P〈0. 05）.The total scores of clinical symptoms and physical signs at the time points of after 4,8,12 weeks of treatment were significantly lower than those before treatment（ P〈0. 05）. The total scores of clinical symptoms and physical signs after 8 weeks of treatment were significantly lower than those after 4 weeks of treatment in the observation group（ P〈0. 05）. The total scores of clinical symptoms and physical signs after 12 weeks of treatment were significantly lower than those after 8 weeks of treatment in the two groups（ P〈0. 05）. The total scores of clinical symptoms and physical signs at the time point of 4 weeks after treatment were significantly lower than

关 键 词：面部激素依赖性皮炎 复方甘草酸苷片 重组牛碱性成纤维细胞生长因子凝胶 

分 类 号：R758[医药卫生—皮肤病学与性病学]