西黄丸的抗肿瘤作用及临床应用研究进展  

Anticancer effects and clinical application of Xihuang pill:research advances

作　　者：邵萌[1] 周太成[2] 殷志新[3] 邬刚[1] 王启瑞[1] SHAO Meng ZHOU Tai-cheng YIN Zhi-xin WU Gang WANG Qi-rui(College of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510315, China the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China School of Basic Medical Science, Southern Medical University, Guangzhou 510315, China)

机构地区：[1]南方医科大学中医药学院,广州510315 [2]中山大学附属六院,广州510655 [3]南方医科大学基础医学院,广州510315

出　　处：《国际药学研究杂志》2017年第6期504-509,共6页Journal of International Pharmaceutical Research

基　　金：广东省中医药局科研课题(20141187);广东省科技计划项目(2014A020221012);广州市珠江科技新星项目(2014J2200092)

摘　　要：西黄丸为具有确切临床疗效的经典抗癌中药名方,其通过抑制肿瘤细胞和肿瘤干细胞的生长及侵袭、抗新生血管生成和逆转免疫抑制微环境等多种途径发挥抗肿瘤作用。本文对西黄丸在治疗结直肠癌、乳腺癌和肝癌等方面的作用机制和临床研究进展进行了综述,为进一步研究和开发西黄丸抗肿瘤的中医药特色治疗提供参考。Xihuang pill,a famous anticancer traditional Chinese medicine formula,has curative effect in clinical application.It can inhibit the growth and invasion of tumor cells and cancer stem cells,prevent angiogenesis,and reverse the tumor immunosuppressive microenvironment. This review summarizes the reported Xihuang pill′ s anticancer mechanism and clinical application on colorectal cancer,breast cancer,liver cancer,so as to provide a reference for the further research and development on anticancer application of Xihuang pill.

关 键 词：西黄丸 抗肿瘤药(中药) 药理作用分子机制 临床应用 结直肠癌 

分 类 号：R286[医药卫生—中药学]