8-氨基喹啉C(5)位C—H键官能化研究进展  

Recent Advances on the C—H Bond Functionalization on C(5) Position of 8-Aminoquinolines

作　　者：朱龙志 曹鑫[1] 李优[1] 刘婷[1] 王勰[1] 邱仁华[1] 尹双凤[1] Zhu Longzhi Cao Xin Li You Liu Ting Wang Xie Qiu Renhua Yin Shuang-Feng(College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082)

机构地区：[1]湖南大学化学化工学院,长沙410082

出　　处：《有机化学》2017年第7期1613-1628,共16页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21373003;21676076);湖南省自然科学基金(No.2016JJ3034);湖湘青年英才计划(No.2016RS3023)资助项目~~

摘　　要：8-氨基喹啉是存在于天然产物和药物分子中的一种重要含氮芳香杂环化合物;可作为有机配体或者双齿导向基团参与一系列有机合成反应,在材料领域也有着广泛应用,因而,受到越来越多的研究者青睐.近年来通过对喹啉母环结构进行位置选择性修饰,构建单取代及多取代喹啉取得了飞速发展.本综述较全面地总结近年来通过碳氢活化方法构建C(5)位取代8-氨基喹啉衍生物的进展,对该领域所存在的问题和局限性进行了总结,并对今后的发展作出展望.8-Aminoquinolines are important nitrogen-containing heterocycles widely existing in the natural products, bio-active molecules and agrochemicals. It has been developed as significant bidentate directing groups or as ligand auxiliary in various kinds of organic reactions, especially in the area of C—H bond functionalization. Therefore, the synthesis of such motifs, especially those with substituted quinolines is of great significance. This review focuses on the remote C—H bond functionalizaitons of 8-aminoquinolines on the C（5） position, including the advantages and disadvantages as well as an outlook in this field.

关 键 词：碳氢键活化 8-氨基喹啉 远程活化 8-氨基喹啉5位 

分 类 号：O626.323[理学—有机化学]