桥本氏甲状腺炎与颈动脉内中膜厚度相关性研究  

Relationship between carotid artery intima-media thickness and Hashimoto's thyroiditis

作　　者：吴婷[1] 刘燕娜[1] 应康[1] WU Ting LIU Yanna YING Kang(Department of Ultrasound, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, China)

机构地区：[1]南昌大学第二附属医院超声科,南昌330006

出　　处：《江西医药》2017年第7期615-616,622,共3页Jiangxi Medical Journal

基　　金：江西省卫计委课题项目;编号20155298

摘　　要：目的探讨桥本氏甲状腺炎(HT)患者中免疫机制和炎性反应与颈动脉内中膜厚度(IMT-CCA)的相关性,判断Tg Ab和TPOAb是否是心脑血管疾病新的独立危险因子。方法将105例HT例女性患者作为观察组,同时选取95例健康体检者作为对照组,分别测定两组研究对象的甲状腺功能、甲状腺抗体水平、胆固醇、甘油三酯、空腹血糖、超敏C-反应蛋白(hs-CRP)及颈总动脉内中膜厚度。结果 HT组与对照组的IMT-CCA之间有统计学意义(0.78±0.10 vs 0.67±0.07,P=0.00),IMT-CCA与Tg Ab、TPOAb、TSH正相关,与FT3、FT4负相关,IMT-CCA与血清hs-CRP呈正相关,多元线性回归分析显示Tg Ab、TPOAb是IMT-CCA的新的独立危险因子。结论桥本氏甲状腺炎患者的IMT-CCA更高,Tg Ab、TPOAb是心血管疾病独立危险因子。自身免疫性甲状腺疾病是能加速动脉硬化进程。Objective To examine whether autoimmune thyroiditis has an effect on the intima-media thickness of the common carotid artery（IMT-CCA）,The aim is to examine whether autoimmune thyroiditis can effect carotid IMT independently of thyroid hormones and cardiovascular risk factors. Methods 105 women with HT and 95 healthy controls were examined in this study,Measurements were made of thyroidfunction、Tg Ab、TPOAb、total cholesterol、triglycerides fasting glycemia、hs-CPR and carotid intima-media thickness. Results The result showed that IMT-CCA in HT was obviously higher than in the control group,and there was significant different between them（0.78±0.10 vs 0.67±0.07,P=0.00）. IMT-CCA were positively correlated with Tg Ab、TPOAb、TSH、hs-CPR and IMT-CCA were negatively correlated with FT3、FT4. Linear multiple regression analysis demonstrated that Tg Ab、TPOAb were independent predictors of IMT-CCA. Conclusion The present study shows that Hashimoto＇s thyroiditis is associated to an increased IMT-CCA,These results suggest that Hashimoto＇s thyroiditis is a marker of evolution of the atherosclerosis.

关 键 词：桥本氏甲状腺炎 颈动脉内中膜 

分 类 号：R581.4[医药卫生—内分泌]