FOXP3翻译后修饰及具有相关功能调节作用的药物研究进展  

Advances in Researches on Posttranslational Modification of FOXP3 and Related Regulatory Drugs

作　　者：赵启航[1,2] 梁瑞[2,3] 李丹[2,3] 李斌[3,4,5] ZHAO Qihang LIANG Rui LI Dan LI Bin(School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China Shanghai Institute of Immunology, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China Savaid Medical School, University of Chinese Academy of Sciences. Beijing 100049,China CAS Center for Excellence in Molecular Cell Science, Shanghai Institutes Jor Biological Sciences, Chinese Academy of Sciences, Shanghai 200031,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009 [2]中国科学院上海巴斯德研究所,上海200031 [3]上海交通大学医学院上海市免疫学研究所,上海200025 [4]中国科学院大学存济医学院,北京100049 [5]中国科学院上海生命科学研究院,中国科学院分子细胞卓越中心,上海200031

出　　处：《药学进展》2017年第7期515-527,共13页Progress in Pharmaceutical Sciences

基　　金：国家重点基础研究发展计划(“973”项目)(No.2014CB541803,No.2014CB541903);国家自然科学基金项目(No.31525008,No.31200647,No.81330072,No.31370863,No.31170825,No.81271835,No.31200646,No.81302532,No.31300711);上海市科委学术委员会基础研究重大重点项目(No.14JC1406100);上海市优秀学术带头人(A类)项目

摘　　要：FOXP3^+调节性T细胞(Treg)是一类发挥免疫抑制及调节功能的T淋巴细胞亚群,其生理功能的可塑性对机体免疫稳态维持至关重要。FOXP3^+Treg功能稳定性的失调与自身免疫疾病、肿瘤、过敏性和感染性疾病等人类重大疾病的发生发展密切相关。Forkhead家族转录因子FOXP3是Treg细胞特异性表达的关键转录因子,其功能稳定性受蛋白翻译后修饰酶类调控。通过筛选中药活性组分,开发靶向FOXP3翻译后修饰酶的小分子药物,从而实现FOXP3^+Treg生理功能调控,将为重大疾病免疫相关治疗带来新思路、新靶点和新手段。FOXP3＇ Regulatory T cell（Treg） is a subset of T cells with the function of immunosuppression and immunoregulation, and its physiological stability plays a significant role in maintaining immune homeostasis in vivo. The instability and malfunction of FOXP3＇ Tregs are implicated in many major human diseases including autoimmune diseases, cancer, allergy and infectious diseases. As a key transcription factor specifically expressed in Treg, the stability of Forkhead family transcription factor FOXP3 is regulated by post-translational modification enzymes. By screening active ingredients in traditional Chinese medicine and developing small molecule drugs targeting FOXP3 post-translational modification enzymes, we expect to modulate the physiological stability of FOXP3＇ Treg and thus bring on new ideas, new targets and new therapeutic tools for the treatment of major human diseases.

关 键 词：调节性T细胞 FOXP3 翻译后修饰 活性调节 

分 类 号：R285[医药卫生—中药学]