两种测定方法对地巴唑片含量影响的探讨  

Effects of Two Methods on the Content of Dibazol Tablets

作　　者：牛其云 郭萍 

机构地区：[1]山东省莱芜市食品药品检验检测中心化药科,莱芜271100

出　　处：《中国医药导刊》2017年第6期624-624,626,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨地巴唑片含量测定的两种方法对地巴唑片质量控制的专属性。方法:选取4个厂家地巴唑片的10批样品分别以高氯酸滴定法和高效液相色谱法(HPLC)测定,比较两种测定方法的专属性。结果:HPLC测定地巴唑片含量的专属性明显优于高氯酸滴定法。结论:采用HPLC测定地巴唑片含量,可有效提高控制地巴唑片质量。Objective：To study the specificity of two methods for the quality control of Dibazol Tablets by Dibazol Tablets.Methods：The 10 batches of samples from Dibazol Tablets from the 4 factories were determined by perchloric acid titration and high performance liquid chromatography（HPLC）,and the specificity of the two methods were compared.Results：The specificity of HPLC for the determination of Dibazol Tablets was significantly better than that of perchloric acid titration.Conclusion：Determination of Dibazol Tablets content by HPLC can effectively improve the quality of Dibazol Tablets.

关 键 词：地巴唑 高氯酸滴定法 高效液相色谱法 

分 类 号：R927.2[医药卫生—药学]