琥珀酸美托洛尔缓释片联合曲美他嗪治疗左心室射血分数保留心力衰竭患者的疗效观察  

Observation of the efficacy of metoprolol succinate sustained-release tablets combined with trimetazidine in the treatment of heart failure patients with preserved left ventricular ejection fraction

作　　者：李思召[1] 谢大昌[1] 刘玉洁[1] 

机构地区：[1]丰县人民医院心内科,江苏丰县221700

出　　处：《徐州医科大学学报》2017年第7期465-467,共3页Journal of Xuzhou Medical University

摘　　要：目的 探讨琥珀酸美托洛尔缓释片联合曲美他嗪对左心室射血分数保留的心力衰竭（heart failure patients with preserved left ventricular ejection fraction,HF-PEF）患者的疗效.方法 选取90例HF-PEF患者,随机分成常规治疗组和联合治疗组,每组45例.常规治疗组给予琥珀酸美托洛尔缓片及抗心力衰竭药物,联合治疗组在此基础上使用曲美他嗪.随访6个月,比较治疗前后2组患者心功能、B型脑钠肽（BNP）、超声心动图左心室舒张功能及6分钟步行试验等指标变化.结果 与常规治疗组相比,联合治疗组心功能改善总有效率明显升高（P〈0.05）,BNP 水平下降（P〈0.01）,舒张早期二尖瓣血流速度与舒张晚期二尖瓣血流速度比值（E/A）升高（P〈0.05）、舒张早期二尖瓣血流速度与舒张早期二尖瓣环运动速度比值（E/e′）下降（P〈0.01）,6分钟步行距离增加（P〈0.01）.结论 琥珀酸美托洛尔缓释片联合曲美他嗪可改善HF-PEF患者心功能和左心室舒张功能,提高生活质量.Objective To observe the efficacy of metoprolol succinate sustained-release tablets combined with trimetazidine in the treatment of heart failure patients with preserved left ventricular ejection fraction （HF-PEF）.Methods A total of 90 patients with HF-PEF were randomly divided into a conventional treatment group and a combined treatment group （n=45）.Patients in the conventional treatment group were administrated with metoprolol succinate sustained-release tablets to treat heart failure,while those in the combined treatment group were given trimetazidine in addition to metoprolol succinate sustained-release tablets.After follow-up visits for six months,the two groups were compared for the New York Heart Association （NYHA） cardiac function,the level of B-type natriuretic peptide （BNP）,the diastolic function of left ventricle and the distance of six minutes walking test before and after treatment.Results Compared with the conventional treatment group,the combined treatment group presented enhanced NYHA cardiac function （P〈0.05）,and showed increases in E/A ratio （P〈0.05） and the distance of six minutes walking test （P〈0.01） but decreases in E/e′ ratio and BNP level （each P〈0.01）.Conclusions The combined use of metoprolol succinate sustained-release tablets and trimentazidine can improve the cardiac function,left ventricular diastolic function and quality of life in patients with HF-PEF.

关 键 词：琥珀酸美托洛尔缓释片 曲美他嗪 左心室射血分数保留的心力衰竭 左心室舒张功能 生活质量 

分 类 号：R541.6[医药卫生—心血管疾病]