慢性阻塞性肺疾病患者肺部感染程度与肺功能的相关性分析  

Correlation analysis between lung function and severity of illness of pulmonary infections in patients with chronic obstructive pulmonary disease

作　　者：潘丽娟[1] 毛毅敏[1] 孙瑜霞[1] 夏云龙[1] 王向迎 王秋颖[1] 

机构地区：[1]河南科技大学第一附属医院呼吸与危重症医学科,河南洛阳471003

出　　处：《中华医院感染学杂志》2017年第14期3161-3164,共4页Chinese Journal of Nosocomiology

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)患者肺部感染严重程度与患者肺功能的相关性,为临床治疗提供参考依据。方法选取2007年9月-2016年3月医院收治的360例COPD合并肺部感染患者根据第一秒用力呼气容积(FEV1)将所有患者分为Ⅰ级组(轻度)124例、Ⅱ级组(中度)102例、Ⅲ级组(重度)86例、IV级组(极重度)48例,比较4组患者临床指标。结果血清降钙素原(PCT)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)水平随肺功能的变差而显著增高(P<0.01),且肺功能IV级患者血清PCT、IL-6、TNF-α、CRP水平均显著高于Ⅲ级者(P<0.05),Ⅲ级者显著高于Ⅱ级者(P<0.05),Ⅱ级者显著高于Ⅰ级者(P<0.05);血清PCT、IL-6、TNF-α、CRP水平与COPD合并肺部感染患者FEV1水平均呈显著负相关(P<0.05)。结论 COPD患者较易发生肺部感染,患者肺功能与肺部感染病情严重程度呈显著负相关,应积极防治COPD患者肺部感染,尽最大可能保护患者肺功能,改善患者活动能力和生活质量。OBJECTIVE To discuss the correlation between lung function and severity of illness of pulmonary infections in patients with chronic obstructive pulmonary disease（COPD）,so as to provide references for clinical treatment.METHODS A total of 360 patients with COPD combined with pulmonary infections from Sep.2007 to Mar.2016 were divided into Class I group（mild,n=124）,ClassⅡ group（moderate,n=102）,ClassⅢ group（severe,n=86）,and Class IV group（extremely severe,n=48）according to the FEV1,then the clinical indexes of the 4groups were compared.RESULTS Levels of serum PCT,IL-6,TNF-α,and CRP were significantly increased with the deterioration of lung functions（P〈0.01）,which in Class IV group were significantly higher than those in ClassⅢ group（P〈0.05）,in ClassⅢ group were significantly higher than those in ClassⅡ group（P〈0.05）,and in ClassⅡ group were significantly higher than those in Class I group（P〈0.05）.FEV1 levels were significantly negatively correlated with serum levels of PCT,IL-6,TNF-αand CRP in patients with COPD combined with pulmonary infections（P〈0.05）.CONCLUSIONCOPD patients are more prone to pulmonary infections,and lung function is significantly negatively correlated with the severity of pulmonary infections.Pulmonary infection should be actively prevented and treated in COPD patients,as far as possible to protect the patient＇s lung function,and improve the quality of life.

关 键 词：慢性阻塞性肺疾病 肺部感染 肺功能 相关性 

分 类 号：R563[医药卫生—呼吸系统]