碳酸氢钠联合氟康唑治疗糖尿病患者口腔真菌感染的疗效评价  

Effect of sodium bicarbonate combined with fluconazole on treatment of diabetes patients complicated with oral fungal infections

作　　者：朱珊 田玉岭 宋绍华 边少峰 李学玉 

机构地区：[1]平煤神马医疗集团总医院口腔科,河南平顶山467000

出　　处：《中华医院感染学杂志》2017年第14期3226-3229,共4页Chinese Journal of Nosocomiology

基　　金：河南省医学科技攻关计划基金资助项目(201404H007)

摘　　要：目的探究碳酸氢钠联合氟康唑治疗糖尿病患者口腔真菌感染的疗效评价。方法对医院2013年2月-2016年2月收治的83例糖尿病合并口腔真菌感染患者作为研究对象,分析感染真菌类型分布及构成;按照随机双盲法将患者分为观察组42例及对照组41例;观察组使用碳酸氢钠联合氟康唑治疗,而对照组仅使用氟康唑治疗;观察两组的治疗效果。结果对83例糖尿病合并口腔真菌感染患者行口腔真菌涂片检查共发现致病菌92株,其中白假丝酵母菌最多占51.09%;两组患者在治疗前口腔PH及白斑面积相差较小,经过不同治疗后,观察组口腔PH及白斑面积分别为(7.52±0.24)及(2.21±1.14)mm^2,均明显优于对照组水平,差异有统计学意义(P<0.05);观察组治愈率为50.00%,总有效率为92.86%,显著高于对照组水平,差异有统计学意义(P<0.05)。结论糖尿病患者合并口腔真菌感染时,以白假丝酵母菌为主要致病菌,使用碳酸氢钠联合氟康唑可显著改善口腔环境,提高治疗效果,值得临床推广使用。OBJECTIVE To explore the effficacy of sodium bicarbonate combined with fluconazole in treatment of diabetes patients complicated with oral fungal infections.METHODS A total of 83 diabetes patients complicated with oral fungal infections who were treated in the hospital from Feb 2013 to Feb 2016 were recruited as the study objects and were randomly divided into the observation group with 42 cases and the control group with 41 cases.The constituent ratios of the species of fungi were analyzed;the observation group was treated with sodium bicarbonate combined with fluconazole,while the control group was only treated with fluconazole,and the therapeutic effect was observed and compared between the two groups.RESULTS The oral fungal smear examination showed that totally 92 strains of pathogens were isolated from the 83 diabetes patients complicated with oral fungal infection,of which 51.09% were Candida albicans.The oral PH and white spot area of the two groups of patients were small before the treatment;the oral PH and white spot area of the observation group were respectively（7.52±0.24）and（2.21±1.14）mm^2 after different treatments,significantly better than those of the control group（P〈0.05）.The cure rate of the observation group was 50.00%,significantly higher than that of the control group;the total effective rate of the observation group was 92.86%,significantly higher than that of the control group（P〈0.05）.CONCLUSION C.albicans is the predominant species of fungi isolated from the diabetes patients complicated with oral fungal infection.Sodium bicarbonate combined with fluconazole may remarkably improve the oral environment and boost the therapeutic effect,and it is worthy to be promoted in the hospital.

关 键 词：碳酸氢钠 氟康唑 糖尿病 口腔真菌感染 

分 类 号：R587.1[医药卫生—内分泌]