可吸入颗粒物在人体呼吸系统沉积的数值模拟与实验研究进展  

Progress in numerical simulation and experimental study on inhalable particles deposition in human respiratory system

作　　者：李蓉[1,2] 赵秀国[1] 刘亚军[1] 徐新喜[1] 

机构地区：[1]军事医学科学院卫生装备研究所,天津300161 [2]武警后勤学院防护医学教研室,天津300309

出　　处：《生物医学工程学杂志》2017年第4期637-642,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(31070832)

摘　　要：可吸入颗粒物在人体呼吸系统沉积是很多呼吸系统和心血管疾病的主要诱因。通过建立计算机或体外实体模型研究颗粒物在呼吸系统内的沉积规律,对相关的疾病预防与治疗有着重要意义。本文将目前学者们对各种模型的上呼吸道及肺腺泡区的可吸入颗粒物沉积研究结果进行了总结分析,阐述了这些研究结果在疾病成因分析、吸入给药治疗等方面的应用。在此基础上,本文提出了现有研究存在的问题及应用局限性,并指出了未来重点研究方向,对于指导可吸入颗粒物沉积模拟、实验和应用方面进一步系统和深入的研究具有较大的参考价值。Inhalable particles deposition in the human respiratory system is the main cause of many respiratory and cardiovascular diseases. It plays an important role in related disease prevention and treatment through establishing computer or external entity models to study rules of particle deposition. The paper summarized and analyzed the present research results of various inhalable particle deposition models of upper respiratory tract and pulmonary area, and expounded the application in the areas of disease inducement analysis, drug inhale treatment etc. Based on the review, the paper puts forward the problems and application limitations of present research, especially pointing out future emphasis in development directions. It will have a value of reference guidance for further systematic and in-depth study on the inhalable particle deposition simulation, experiment and application.

关 键 词：可吸入颗粒物 人体呼吸系统 沉积 数值模拟 体外模型 

分 类 号：R12[医药卫生—环境卫生学]