熊胆缓释滴眼凝胶兔眼内药代动力学研究  

Study on pharmacokinetics of bear gall sustained release ophthalmic gel in the rabb it eyes

作　　者：杨辛欣[1] 车燚[1] 李超英[1] 魏中原[1] 

机构地区：[1]长春中医药大学药学院,吉林长春130117

出　　处：《时珍国医国药》2017年第7期1634-1636,共3页Lishizhen Medicine and Materia Medica Research

基　　金：吉林省产业技术研究与开发项目(No.2013C017-3)

摘　　要：目的建立熊胆滴眼凝胶兔眼药代动力学研究方法,考察熊胆滴眼凝胶给药前后药物在体内的释药规律。方法采用高效液相色谱法测定眼用凝胶制剂给药后药物熊胆在家兔眼内不同时间点的滞留量和眼组织中药物含量,并与等剂量普通滴眼剂(牛磺熊去氧胆酸钠)比较。结果熊胆滴眼凝胶与普通滴眼剂中药物含量与时间曲线具有显著差异。眼用凝胶剂提高了兔眼中的药物浓度,且能延长药物在眼中的滞留时间。结论研制的新型眼用凝胶制剂具有缓释效果,且较滴眼液生物利用度显著提高。Objective To establish ophthalmic gel in vivo evaluation method and research drug release regularity. Methods HPLC at different time points lagophthalmos retention and lagophthalmos organization cow sulfonylurea bear deoxycholic acid content. Results To compare with ordinary eye drops,experimental drug with drug content curve had significant differences,gel preparation can reach delayed release effect. Conclusion Compare with eye drops,Chinese medicine complex prescription ophthalmic gel have higher drug concentrations and can maintain longer time. It is bioavailability obviously increased than eye drops.

关 键 词：眼用凝胶 药代动力学 熊胆 

分 类 号：R285.5[医药卫生—中药学]