穴位埋线配合隔姜灸治疗脾肾阳虚型慢性疲劳综合征的疗效分析及其对T淋巴细胞亚群和NK细胞活性的影响  

Efficacy of acupoint catgut embedding combined with ginger-partitioned moxibustion on chronic fatigue syndrome of spleen-kidney yang deficiency syndrome and its effects on T lymphocyte subsets and activity of NK cell

作　　者：夏德鹏[1] 陈培芳[1] 杜培学 丁立钧 刘安利[1] 

机构地区：[1]日照市中医医院针灸推拿二科,山东日照276800

出　　处：《中国针灸》2017年第8期814-818,共5页Chinese Acupuncture & Moxibustion

摘　　要：目的:观察穴位埋线配合隔姜灸与常规针刺对比治疗脾肾阳虚型慢性疲劳综合征的临床疗效差异及其对T淋巴细胞亚群和自然杀伤细胞(NK)细胞活性的影响。方法:将60例脾肾阳虚型慢性疲劳综合征患者随机分为埋线隔姜灸组与常规针刺组,每组30例。埋线隔姜灸组采用穴位埋线配合隔姜灸治疗,穴位埋线穴取关元、肾俞、脾俞、足三里、气海,每周治疗1次;隔姜灸穴取关元、气海、足三里,每3天治疗1次,均连续1个月。常规针刺组采用常规针刺,穴取关元、肾俞、脾俞、足三里、气海,每天治疗1次,每周治疗6次,休息1 d,连续1个月。观察两组患者治疗前后的临床症状积分、疲劳量表-14积分、疲劳评定量表积分、实验室指标及临床疗效。结果:(1)两组治疗后临床症状积分、疲劳量表-14积分和疲劳评定量表积分均较本组治疗前降低,差异均有统计学意义(均P<0.05);治疗后,埋线隔姜灸组临床症状积分、疲劳量表-14积分和疲劳评定量表积分均低于常规针刺组,差异均有统计学意义(均P<0.05);(2)两组治疗后血清CD_4^+/CD_8^+、NK%、CD_3^+%、CD_4^+%均高于治疗前,差异均有统计学意义(均P<0.05);治疗后埋线隔姜灸组血清CD_4^+/CD_8^+、CD_3^+%、CD_4^+%均高于常规针刺组,差异均有统计学意义(均P<0.05);(3)治疗后,埋线隔姜灸组总有效率为96.7%(29/30),常规针刺组总有效率为93.3%(28/30),差异无统计学意义(P>0.05)。结论:穴位埋线配合隔姜灸能够有效改善症状,调节脾肾阳虚型慢性疲劳综合征患者T淋巴细胞亚群水平及NK细胞活性,是治疗脾肾阳虚型慢性疲劳综合征的有效方法。Objective To observe the efficacy differences between acupoint catgut embedding combined with ginger-partitioned moxibustion and regular acupuncture on chronic fatigue syndrome（CFS） of spleen-kidney yang deficiency syndrome, and to explore its effects on T lymphocyte subsets and activity of NK cell. Methods A total of 60 patients with CFS of spleen-kidney yang deficiency syndrome were randomly divided into a catgut embedding combined with ginger-partitioned moxibustion（CECGP） group and a regular acupuncture group, 30 cases in each one. The patients in the CECGP group were treated with acupoint catgut embedding combined with ginger-partitioned moxibustion; the acupoint catgut embedding was applied at Guanyuan（CV 4）, Shenshu（BL 23）, Pishu（BL 20）, Zusanli（ST 36）, Qihai（CV 6）, once a week, while the ginger-partitioned moxibustion was applied at Guanyuan（CV 4）, Qihai（CV 6） and Zusanli（ST 36）, once every three days for consecutive one month. The patients in the regular acupuncture group were treated with regular acupuncture at Guanyuan（CV 4）, Shenshu（BL 23）, Pishu（BL 20）, Zusanli（ST 36）, Qihai（CV 6）, once a day, 6 treatments per week（one day for rest） for consecutive one month. The clinical symptom scores, fatigue scale-14（FS-14）, fatigue assessment instrument（FAI）, laboratory test results and total effective rate were compared between the two groups before and after treatment. Results（1） After treatment, the clinical symptom scores, FS-14 and FAI were reduced in the two groups（all P〈0.05）; after treatment, the clinical symptom scores, FS-14 and FAI in the CECGP group were significantly lower than those in the regular acupuncture group（all P〈0.05）.（2） After treatment, theCD4＋/CD8＋, natural killer cell%（NK%）, CD3＋ %, CD4＋ % were all increased in the two groups（all P〈0.05）; theCD4＋/CD8＋,CD3＋ %, CD4＋ % in the CECGPgroup were significantly higher than those in the regular acupuncture group（all P〈0.05）

关 键 词：慢性疲劳综合征 穴位埋线 隔姜灸 T淋巴细胞亚群水平 NK细胞活性 

分 类 号：R246.1[医药卫生—针灸推拿学]