隔药灸脐法治疗排卵障碍性不孕症:随机对照试验  

Herb-partitioned moxibustion on navel for anovulatory infertility:a randomized controlled trial

作　　者：李昭凤[1] 王辉 郝明耀[3] 王璇[4] 于岩瀑[5] 马玉侠[5] 

机构地区：[1]山东中医药大学,济南250355 [2]昌邑市昌城医院 [3]山东中医药大学附属医院 [4]山东中医药大学第二附属医院 [5]山东中医药大学针灸推拿学院,济南250355

出　　处：《中国针灸》2017年第8期819-823,共5页Chinese Acupuncture & Moxibustion

基　　金：山东省科技惠民计划项目:2014kjhm0111;山东省科技发展计划:2014GSF118154

摘　　要：目的:观察隔药灸脐法与克罗米芬(CC)治疗排卵障碍性不孕症的疗效差异。方法:采用双盲双模拟的随机对照方法,将40名排卵障碍性不孕症患者随机分为隔药灸脐组和克罗米芬组,每组20例。对患者和操作者实施双盲。隔药灸脐组采用隔药灸脐法和口服CC模拟剂的治疗方法,克罗米芬组采用隔模拟剂灸脐法和口服CC的治疗方法。隔药灸脐或隔模拟剂灸脐均在每次月经结束后开始治疗,每周1次,每次施灸1.5 h,月经期不治疗;口服CC或CC模拟剂均自月经来潮第5 d起,口服50 mg CC或CC模拟剂,每日1次,连用5 d。1个月经周期为一疗程,连续治疗3个疗程。3个疗程后,观察两组患者子宫内膜厚度、最大卵泡直径和排卵率,并比较两组的临床疗效。结果:(1)两组子宫内膜厚度治疗后均较治疗前增厚,治疗前后差异有统计学意义(均P<0.05);治疗后,隔药灸脐组厚于克罗米芬组,差异有统计学意义(P<0.05)。(2)隔药灸脐组最大卵泡直径治疗后较治疗前增大,治疗前后差异有统计学意义(P<0.05);克罗米芬组最大卵泡直径治疗后较治疗前增大,但差异无统计学意义(P>0.05);治疗后隔药灸脐组最大卵泡直径大于克罗米芬组,差异有统计学意义(P<0.05)。(3)治疗后,两组排卵率分别为75.0%(15/20)和65.0%(13/20),差异无统计学意义(P>0.05)。(4)隔药灸脐组总有效率为95.0%(19/20),优于克罗米芬组的70.0%(14/20,P<0.05)。结论:隔药灸脐法较口服CC临床疗效更好,两组在改善排卵率方面疗效相当。Objective To observe the efficacy differences between herb-partitioned moxibustion on navel and clomiphene for anovulatory infertility. Methods With double-blind double-dummy randomized control method, a total of 40 patients with anovulatory infertility were randomly divided into a moxibustion group and a clomiphene group, 20 cases in each one. Blinding was conducted on both patients and doctors. The patients in the moxibustion group were treated with herb-partitioned moxibustion on navel and oral administration of clomiphene placebo, while the patients in the clomiphene group were treated with placebo-partitioned moxibustion on navel and oral administration of clomiphene. The herb-partitioned moxibustion and placebo-partitioned moxibustion were given at the end of menstruation, 1.5 hours per treatment, once a week, and no treatment was given during menstruation. The oral administration of clomiphene and clomiphene placebo were given from 5 days into menstruation, 50 mg, once a day, for consecutive 5 days. One menstrual cycle was taken as one treatment course, and 3 treatment courses were conducted. After 3 treatment courses, the endometrial thickness （ET）, maximum follicular diameter （MFD）, ovulation rate （OR） and effective rate （ER） were evaluated between the two groups. Results （1） Compared before treatment, ET was significantly increased after treatment in the two groups （both P〈 0.05）; after treatment, the ET in the moxibustion group was higher than that in the clomiphene group （P〈 0.05）. （2） After treatment, MFD was significantly increased in themoxibustion group （P〈 0.05） and insignificantly increased in the clomiphene group （P〉 0.05）; the MFD in the moxibustion group was higher than that in the clomiphene group （P〈 0.05）. （3] The OR was 75.0% （15/20） and 65.0% （13/20） in the two groups respectively, which were not significantly different （P〉 0.05）. （4） The total ER in the moxibustion group was 95.0% （19/20）, which was superior t

关 键 词：排卵障碍性不孕症 隔药灸脐法 克罗米芬 随机对照组试验 

分 类 号：R246.3[医药卫生—针灸推拿学]