我院动物骨多肽类药物致不良反应96例分析  

Analysis of 96 Cases of ADR Induced by Animal Bone Polypeptide Medicine in Our Hospital

作　　者：殷娜[1] 张云芳[1] 

机构地区：[1]河南省洛阳正骨医院(河南省骨科医院)临床药学研究室,河南洛阳471002

出　　处：《中国药房》2017年第23期3217-3219,共3页China Pharmacy

摘　　要：目的:探讨动物骨多肽类药物所致不良反应(ADR)的发生特点及规律,为临床合理使用该类药物提供参考。方法:回顾性分析2009年1月-2016年6月我院动物骨多肽类药物ADR发生情况,对96例ADR从患者性别、年龄、涉及药品、发生时间、给药途径、累及器官/系统、关联性及转归等方面进行统计分析。结果:96例ADR(含17例严重的ADR)病例中,男女比例为1.34∶1;40岁以上患者居多(56.25%);ADR多发生在用药后15 min内(39.58%),以静脉滴注为主;ADR累及器官/系统主要为皮肤及其附件损害(34.81%),其次为呼吸系统损害(18.35%)和全身性损害(16.46%);ADR关联性为很可能的有41例(42.71%),可能的有55例(57.29%);出现ADR并给予停药或相应处理后43例(44.79%)患者痊愈,53例(55.21%)患者症状有所好转。结论:医护人员应掌握动物骨多肽类药物致ADR的发生规律及特点,加强合理用药管理及临床用药监护,以保障临床用药的安全性及有效性。OBJECTIVE：To explore the feature and regularity of ADR induced by animal bone polypeptide medicine,so as to provide reference for rational use of these drugs in clinical practice. METHODS：In retrospective analysis,96 cases of ADR occurred in our hospital during Jan. 2009-Jun. 2016 were analyzed statistically in terms of patients＇ gender and age,drugs involved,occurrence time,route of administration,organs and systems involved,association,prognosis,etc. RESULTS：Among 96 cases（including 17 serious ADR）,the ratio of male to female was 1.34 ∶ 1,and 56.25% of them were above 40 years old. ADR mainly occurred within 15 minutes after medication（39.58%）dominated by intravenous drip. Organs/systems involved in ADR were mainly lesion of skin and its appendants（34.81%）,followed by respiratory system damage（18.35%）and systemic damage（16.46%）.In aspect of ADR association,41 were probable（42.71%）and 55 were possible（57.29%）. After suffering from ADR,43 patients（44.79%）were cured after drug withdrawal or corresponding treatment,and 53 patients（55.21%）were recovered. CONCLUSIONS：Medical staff should master the regularity and characteristics of ADR induced by animal bone polypeptide medicine,while strengthen rational drug use management and monitoring to ensure the safety and effectiveness of clinical drug use.

关 键 词：动物骨多肽类药物 药品不良反应 合理用药 

分 类 号：R969.3[医药卫生—药理学]