鸭致病性大肠杆菌研究进展  

Research progress on avian pathogenic Escherichia coli of duck

作　　者：孙畅[1] 牛银杰 尹海畅[1] 徐丽晶[1] 陈洪岩[1] 弥春霞[2] 赵丽丽[1] 

机构地区：[1]中国农业科学院哈尔滨兽医研究所/兽医生物技术国家重点实验室,哈尔滨150069 [2]牡丹江师范学院生命科学与技术学院,黑龙江牡丹江157011

出　　处：《黑龙江畜牧兽医》2017年第8期72-77,共6页Heilongjiang Animal Science And veterinary Medicine

基　　金："十二五"国家科技支撑计划项目(2015BAI07B02-02)

摘　　要：近年来,由禽致病性大肠杆菌(avian pathogenic Escherichia coli,APEC)引起的禽大肠杆菌病给全球的养禽行业造成了重大的经济损失,并且APEC引起的禽大肠杆菌病在中国是最主要的家禽细菌病。越来越多的证据显示,APEC是人源尿路感染大肠杆菌(uropathogenic Escherichia coli,UPEC)和致脑膜炎大肠杆菌(neonatal meningitis Escherichia coli,NMEC)的毒力基因储藏库,甚至可能会直接导致两种疾病的发生。因此,如何有效地控制APEC不仅是一个紧迫的问题,更是一个巨大的挑战。对APEC的分离鉴定、流行病学特征、药物敏感性等内容的研究对APEC引起的禽大肠杆菌病的控制具有指导意义。为了更好地防控大肠杆菌病,文章主要从临床症状、病理变化、毒力因子、致病机理和诊断方法几个方面对鸭致病性大肠杆菌进行了综述,以期为进一步研究提供参考。In recent years, avian pathogenic Escherichia coli （ APEC ） were responsible for avian colibacillosis and caused significant economic losses in the poultry industry worldwide. Avian colibacillosis caused by APEC was the predominant bacterial disease of poultry in China. Mount- ing evidence had revealed that APEC caused UPEC and NMEC in human beings as a vehicle or even a reservoir. Therefore, the effective meas- ures of APEC control had become an urgent issue, also a great challenge. The isolation and identification of APEC, analysis of molecular epide- mialogical characteristic, sensitivity test played an important role in controlling avian colibacillosis. For better control and prevention of the avi- an pathogenic Escherichia coli, the article summarized the clinical symptoms, pathological changes, virulence factors, pathogenesis and diagno- sis to provide further research reference.

关 键 词：鸭 大肠杆菌病 毒力因子 致病机理 诊断方法 

分 类 号：S834[农业科学—畜牧学] S852.61[农业科学—畜牧兽医]