促骨再生BMP-2缓释材料的研究进展  

Research Progress of BMP-2 Sustained Release Materials for Bone Regeneration

作　　者：孟会强 郭来威 许田恩 夏亚一[1,2] 

机构地区：[1]兰州大学第二医院,兰州730000 [2]甘肃省骨关节疾病研究重点实验室,兰州730000

出　　处：《世界科技研究与发展》2017年第4期349-354,共6页World Sci-Tech R&D

基　　金：国家自然科学基金(81450042;81071478);甘肃省卫生行业计划(GSWST2011-072);兰州市科技发展计划(2014-2-27)资助

摘　　要：骨形态发生蛋白-2(BMP-2)属于TGF-β(β转化生长因子超家族),是目前成骨活性最强、研究最广泛的骨生长因子。BMP-2等外源性生长因子稳定性不好、体内半衰期短,需要大剂量、多次应用,因此,研究BMP-2的缓释方法具有重要意义。本文对BMP-2的促骨再生作用、不同类型的BMP-2缓释载体及其选择原则、不同类型的缓释材料的研究及其他较为新颖的BMP-2缓释材料的研究等进行综述,提出研发生物相容性更好、载药率更高的可降解的新型载体等将是未来研究的重点方向。Bone morphogenetic protein -2 （ BMP-2 ）, which belongs to the TGF-beta （ transforming growth factor beta）, is the most active and widely studied bone growth factor. BMP-2 is volatile and short in terms of its half-life in vivo, so it has to be applied in large doses and for multiple times. Therefore, the study of sustained release of BMP-2 is of great significance. In this paper, the role of BMP-2 in promoting bone regeneration, different types of sustained release carriers and their selec- tion principles,study of the sustained-release materials of different forms and other relatively new BMP-2 sustained-release materials research are summarized. It is the key direction of future research to develop a new biodegradable carrier material with better biocompatibility and higher drug loading rate.

关 键 词：骨形态发生蛋白-2 骨再生 缓释 载体 

分 类 号：R318.08[医药卫生—生物医学工程]