脑苷肌肽注射液联合鼠神经生长因子注射剂治疗重症颅脑损伤的临床研究  

Clinical trial of cattle encephalon glycoside and ignotin injection combined with mouse nerve growth factor injection in the treatment of severe craniocerebral injury

作　　者：陆斌[1] 陈思[1] 

机构地区：[1]唐山工人医院神外一科,河北唐山063000

出　　处：《中国临床药理学杂志》2017年第15期1397-1399,共3页The Chinese Journal of Clinical Pharmacology

基　　金：河北省医学科学研究重点课题计划基金资助项目(ZL20140228)

摘　　要：目的观察脑苷肌肽注射液联合鼠神经生长因子注射剂治疗重症颅脑损伤的临床疗效及安全性。方法将80例重症颅脑损伤患者随机分作对照组40例与试验组40例。对照组予以脑苷肌肽注射液10 m L,静脉滴注,bid;试验组在对照组治疗的基础上,予以注射用鼠神经生长因子30μg,肌内注射,bid。2组患者均治疗4周。比较2组患者的临床疗效、神经功能缺损评分(NIHSS)和药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为95.00%(38/40例)和75.00%(30/40例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的NIHSS评分分别为(10.94±1.31)和(15.24±1.59)分,差异有统计学意义(P<0.05)。对照组发生的药物不良反应主要有头晕和烦躁,试验组发生的药物不良反应主要有局部疼痛和皮疹。试验组和对照组的药物不良反应发生率分别为7.50%和15.00%,差异无统计学意义(P>0.05)。结论脑苷肌肽注射液联合鼠神经生长因子注射剂治疗重症颅脑损伤的临床疗效确切,且不增加药物不良反应发生率。Objective To observe the clinical efficacy and safety of cattle encephalon glycoside and ignotin injection combined with mouse nerve growth factor injection in the treatment of severe craniocerebral injury.Methods A total of 80 patients of severe craniocerebral injury were divided into control group and treatment group with 40 cases per group.Control group was treated cattle encephalon glycoside and ignotin injection 10 m L,intravenous drip,bid. Treatment group was given mouse nerve growth factor injection 30 μg,intramuscular injection,bid,on the basis of control group. Two groups were treated for 4 weeks. The clinical efficacy,neurological deficit score（ NIHSS）,and adverse drug reactions were compared between two groups. Results After treatment,the total effective rates in treatment and control groups were 95. 00%（ 38/40cases） and 75. 00%（ 30/40 cases） with statistically significant difference（ P〈0. 05）. After treatment,the NIHSS in treatment and control groups were（ 10. 94 ± 1. 31）,（ 15. 24 ± 1. 59） points, with significant difference（ P〈0. 05）. The adverse drug reactions in treatment group were local pain and rash,which in control group were dizziness andirritability. The incidences of adverse drug reactions in treatment and control groups were 7. 50% and 15. 00% without significant difference（ P〈0. 05）. Conclusion Cattle encephalon glycoside and ignotin injection combined with mouse nerve growth factor injection has a definitive clinical efficacy in the treatment of severe craniocerebral injury,without increasing the incidence of adverse drug reaction.

关 键 词：脑苷肌肽注射液 鼠神经生长因子注射剂 重症颅脑损伤 安全性 

分 类 号：R97[医药卫生—药品]