生长分化因子-15水平与急性冠脉综合征患者心功能分级的相关性  

Correlation between the Levels of GDF-15 and Heart Function Classification in Acute Coronary Syndrom

作　　者：金鸣锋[1] 周烨[1] 陈广华[1] 丁澍[1] 王翠平[1] JIN Ming-feng ZHOU Ye CEIEN Guang-hua et al(Affiliated Hospital of Jiangsu University , Zhenjiang212001, China)

机构地区：[1]江苏大学附属医院,江苏镇江212001

出　　处：《中外医学研究》2017年第23期25-27,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：国家自然科学基金青年基金项目(项目编号:81400269);镇江市社会发展基金项目(项目编号:SH2015041);江苏大学临床医学专项基金项目(项目编号:JDLCZX019)

摘　　要：目的:对生长分化因子-15水平(growth differentiation factor-15,GDF-15)与急性冠脉综合征(acute coronary syndrome,ACS)患者心功能分级的临床意义进行研究。方法:58例ACS患者按纽约心脏病协会(NYHA)的心功能分级方法分为NYHAⅠ级组(21例)、NYHAⅡ级组(22例)、NYHAⅢ级组(10例)、NYHAⅣ级组(5例)四个亚组。25例行冠脉造影排除冠心病的NYHAⅠ级患者为对照组。检测各组B型利钠肽(B-type natnuretic peptide,BNP)等生化指标,运用ELISA法测定GDF-15水平。结果:与对照组相比,ACS患者各亚组的GDF-15、BNP水平显著高(P<0.01),且各组GDF-15、BNP水平随着心力衰竭严重程度的升高而上升(P<0.05),GDF-15、BNP水平均与心衰程度呈正相关(r=0.681、0.653,P<0.001)。且GDF-15、BNP两者间亦呈现正相关性(r=0.726,P<0.001)。结论:ACS患者的GDF-15水平升高显著,与BNP呈正相关,可对ACS患者的心功能进行较有价值的危险分层,利于判定ACS患者心力衰竭程度。Objective： To approach the clinical significance between the levels of growth differentiation factor-15（GDF-15） and the heart function classification in acute coronary syndrome（ACS）.Method： 58 ACS patients were divided into four sub-groups such as Ⅰ degree（21 cases）, Ⅱ degree（22 cases）, Ⅲ degree（10 eases）, Ⅳ degree（5 cases） according to the New York heart association（NYHA）.25 cases with Ⅰ degree of NYHA excluded coronary artery disease by coronary arteriography were treated as the control group.Biochemical indicators such as B-type namuretic peptide（BNP） were tested in all groups.The levels of GDF- 15 were determined by antibody-sandwich enzyme - linked immunosorbent assay（ELISA）.Result： Compared with the control group, the analysis showed that the levels of GDF-15, BNP in ACS sub-groups were significantly increased（P〈0.01）, and the levels of GDF-15, BNP expression increased with the degree of heart failure increased（P〈0.05）, also the levels of GDF-15, BNP in ACS patients had a positive correlation with the degree of heart failure（r=0.681, 0.653, P〈0.001）. Then the GDF-15 was positively correlated with BNP（r=0.726, P〈0.001）.Conclusion： The levels of GDF-15 in ACS patients are markedly increased, also has a positive correlation with BNP.They have more valuable to evaluate the risk stratification of the heart function, also can be used to judge the severity of heart failure in ACS patients.

关 键 词：生长分化因子-15 急性冠脉综合征 B型利钠肽 

分 类 号：R541.4[医药卫生—心血管疾病]