醋酸去氨加压素联合索利那新对原发性遗尿症的疗效分析  

Efficacy of solifenacin with desmopressin acetate monotherapy on children with monosymptomatic nocturnal enuresis

作　　者：刘杰[1] 岑敏[2] 王冠[1] Liu Jie Cen Min Wang Guan(Department of Pediatrics Department of Pediatrics in Pu -ai Hospital District, Huangshi Central Hospital, Edong Healthcare Group, Huang Shi435000, China)

机构地区：[1]鄂东医疗集团黄石市中心医院(湖北理工学院附属医院) 儿科,湖北黄石435000 [2]鄂东医疗集团黄石市中心医院(湖北理工学院附属医院) 普爱院区儿科,湖北黄石435000

出　　处：《国际泌尿系统杂志》2017年第4期539-542,共4页International Journal of Urology and Nephrology

摘　　要：目的 观察儿童单症状性夜间遗尿症患者在接受醋酸去氨加压素治疗疗效欠佳后加用索利那新的疗效.方法 选取2013年6月至2016年3月在本院儿科和泌尿科治疗的211例夜间遗尿症患儿,采用随机数字表法分为两组,分别给予0.1 mg组（104例）和0.2 mg组（107例）0.1 mg/d、0.2 mg/d醋酸去氨加压素进行治疗,疗程持续2周.再用随机数字表的方法将使用醋酸去氨加压素疗效未达有效标准的122例患儿分为观察组和对照组,两组患儿均给予0.2 mg醋酸去氨加压素治疗,60例观察组患儿加用索利那新1/3片（5 mg/片）,62例对照组加用安慰剂.两组均治疗4周并随访4个月,记录两组患儿疗效及复发率.结果 0.1 mg组和0.2 mg的有效率为40.3%（42/104）、38.3%（41/107）,差异无统计学意义（P〉0.05）,随访4个月后,0.1 mg组复发率65.7%（23/35）高于0.2 mg组复发率40.5%（15/37）,差异具有统计学意义（P〈0.05）.观察组患儿的有效率为28.3%（17/60）高于对照组的4.8%（3/62）,观察组患儿的无效率和复发率为46.7%（28/60）、30.8%（8/26）低于对照组的79.0%（49/62）、70.0%（7/10）,差异均具有统计学意义（P〈0.05）.结论 运用高剂量醋酸去氨加压素治疗儿童单症状性夜间遗尿症能够降低复发率,联合索利那新治疗可提高疗效,进一步减少复发.Objectives To observe the therapeutic effect of solifenacin on children with monosymptomatic nocturnal enuresis who have poorefficacy after treatment with desmopressin acetate monotherapy.Methods Two hundreds children with monosymptomatic nocturnal enuresis who admitted into our hospital from June 2013 to March 2016 were randomly divided into two groups：0.1 mg group with 104 caseswere given 0.1 mg desmopressin, 0.2 mg group with 107 cases were treated with 0.2 mg desmopressin, the treatment course was 2 weeks.The children received desmopressin monotherapy with a failure were randomly divided into observation group and control group, 60cases in observation group were given desmopressin combined with 1/3 pill solifenacin,while 62 cases in control group received desmopressin combined with placebo,the treatment course last for 4 weeks and follow up for 4 months, the curative effect and recurrence rate of 2 groups were recorded.Results The effective rate in 0.1 mg group and 0.2 mg group was 40.3%（42/104） and 38.3%（41/107） respectively, with statistically significant difference（P〉0.05）,the recurrence rate in 0.1 mg group was significantly higher than that in 0.2 mg group four months later[65.7%（23/35） vs.40.5%（15/37）,P〈0.05）].The effective rate in observation group was significantly higher than in control group [28.3%（17/60） vs.4.8%（3/62）], no efficiency and recurrence rate in observation group were significantly lower than incontrol group [46.7%（28/60）vs.79.0%（49/62）,30.8%（8/26）vs.70.0%（7/10）],the differences were statistically significant （P〈0.05）.Conclusions The high dose of desmopressin in treatment of children with monosymptomatic nocturnal enuresis can reduce the recurrence rate, it combined with the solifenacin can improve the curative effect and get the further reduction in recurrence.

关 键 词：夜遗尿症 脱氨基精氨酸血管升压素 醋酸 

分 类 号：R726.9[医药卫生—儿科]