复发性卵巢上皮癌女性患者无瘤生存状况及其影响因素分析  

Disease-freeinterval conditions and influencing factors of patients with recurrent epithelial ovarian cancer

作　　者：黄志有[1] 马必东 黄兆明[1] HUANG Zhi-you MA Bi-dong HUANG Zhao-ming(Department of Oncology, Wenzhou Hospital of Traditional Chinese Medicine, Zhejiang Wenzhou 325000, Chin)

机构地区：[1]温州市中医院肿瘤科,浙江温州325000

出　　处：《中国妇幼健康研究》2017年第7期788-789,896,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨复发性卵巢癌女性患者经不同治疗后的无瘤生存状况及其影响因素。方法选取2013年9月至2015年11月于温州市中医院肿瘤科接受治疗的68例复发性卵巢癌妇女患者,对其临床资料进行回顾性分析,根据治疗方案不同分为对照组(n=33)和观察组(n=35),对照组接受铂类和紫杉醇为主的单纯化疗,观察组在对照组的基础上联合二次肿瘤细胞减灭术治疗,比较两组患者无瘤生存状况。结果观察组患者显效、总有效显著高于对照组患者(χ~2值分别为4.845、4.177,均P<0.05),且复发后第2年、3年、4年生存率均显著高于对照组患者(χ~2值分别为4.001、4.220、4.839,均P<0.05)。患者初次术后残余病灶大小、分期、组织学分级与无瘤生存期显著相关(Z值分别为-5.128、-9.196、8.124,均P<0.05),而病理类型与无瘤生存期无显著相关性(Z=1.600,P>0.05)。患者初次术后残余病灶大小、分期、组织学分级是无瘤生存期的影响因素(OR值分别为2.908、2.024、1.906,均P<0.05)。结论化疗联合二次肿瘤细胞减灭术可提高患者复发后的生存率。Objective To investigate the disease-freeinterval（DFI） conditions and influencing factors of women with recurrent epithelial ovarian cancer. Methods Retrospective analysis was conducted on clinical data of 68 women with recurrent ovarian cancer receiving treatment in department of oncology in Wenzhou Hospital of Traditional Chinese Medicine from September 2012 to November 2016.According to different treatment,patients were divided into control group（ n = 33） and observation group（ n = 35）. The control group accepted simple chemotherapy mainly based on platinum and paclitaxel,while the observation group received secondary cytoreductive surgery based on the therapy for the control group. DFI of two groups was compared. Results The remarkable effect and total response in the observation group were significantly higher than in the control group（ χ2value was 4. 845 and 4. 177,respectively,both P〈 0. 05）,and the survival rates 2 years,3 years and 4 years after recurrence were significantly higher than the control group（ χ2value was 4. 001,4. 220 and 4. 839,respectively,all P〈 0. 05）. Residual lesion size,stage and histological grade after initial surgery of patients were significantly associated with DFI（ Z value was-5. 128,-9. 196 and 5. 128,respectively,all P〈 0. 05）,but the pathological type was not significantly associated with DFI（ Z = 1. 600,P〈 0. 05）. The residual lesion size,stage and histological grade of the patients after initial surgery were the influencing factors of DFI（ OR value was 2. 908,2. 024 and 1. 906,respectively,all P〈 0. 05）. Conclusion Chemotherapy and secondary cytoreductive surgery can improve the survival rate of patients after recurrence.

关 键 词：复发性卵巢癌 二次肿瘤细胞减灭术 无瘤生存 影响因素 

分 类 号：R711.7[医药卫生—妇产科学]