汉以降著名医家胸痹学术思想数据挖掘研究  

Data Mining Research on Academic Thought of Treating Chest Pain from Famous Medicalists since the Han Dynasty

作　　者：吴海芳[1,2] 何庆勇[1] 廖江铨[1,2] 刘旭东[1,2] 钟小雪 杨韬[1,2] Wu Haifang He Qingyong Liao Jiangquan Liu Xudong Zhong Xiaoxue Yang Tao(Guang＇anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China Beijing University of Chinese Medicine, Beijing 100029, China)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029

出　　处：《世界科学技术-中医药现代化》2017年第4期674-679,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委青年科学基金项目(81202803):运脾化浊法干预血脂异常大鼠microRNA-33调控脂肪细胞因子信号通路的研究;负责人:何庆勇;中国中医科学院中央公益性科研院所基本科研业务费专项资金资助项目(ZZ0908023):运脾化浊法对血脂异常患者促炎因子及内皮功能的影响;负责人:何庆勇

摘　　要：目的:分析汉以降著名医家治疗胸痹方剂配伍规律,为临床治疗胸痹及研发中药新药提供依据。方法:录入汉至清著名医家著作中治疗胸痹的101首方剂,运用中医传承辅助系统(V2.5)中证候统计、药物频次、关联规则、复杂网络、熵方法分析其配伍规律。结果:提取出治疗胸痹方剂中最常见的单药有:桂枝,40次(占39.6%)等;最常见的对药有:甘草-茯苓,21次(占20.8%)等;最常见的角药有:生姜-半夏-桂枝,13次(占12.9%)等;基于关联规则发现常见药物组合有:桂枝,前胡→生姜(置信度0.909 1);基于复杂网络发现核心药物有:桂枝,甘草等;通过熵方法提取出的新方组合有:薤白、桂枝、茯苓、杏仁等11个新处方。结论:研究发现古代医家治疗胸痹方剂是有配伍规律可循的,提示今后治疗胸痹及研发中药新药可从以下6个方面着手:(1)单味药可优先选择:桂枝等;(2)对药可优先选择:甘草-茯苓等;(3)角药可优先选择:生姜-半夏-桂枝等;(4)注重药物配伍关系,可优先选择关联度高的组合:桂枝,前胡→生姜等;(5)以核心治法为主,运用核心药物,适当配伍:如温阳驱寒法,核心药物为桂枝,可配伍生姜等;(6)应用新方:薤白、桂枝、茯苓、杏仁等。The analysis on regularity of comparability among famous physician＇s prescriptions for treating chest pain since the Han Dynasty will be helpful to treat chest pain and develop new herbs. The Chinese Medicine Auxiliary System （V2.5） was used to analysis the regularity of comparability by inputting the most famous 101 prescriptions for the treatment of chest pain from the Han Dynasty to Qing Dynasty. The results showed that the most common single drugs were cassia twig, 40 times （39.6%）. The most common couplet medicines were licorice and poria cocos, 21 times （20.8%）. The most common triangle medicines were ginger, pinellia, and cassia twig, 13 times （12.9%）. The most common drug combination based on association rules was the combination of cassia twig, peucedani radix--ginger （confidence level of 0.909 1）. The core drugs based on complex network was cassia twig, licorice, and etc. New prescription combinations based on the entropy method were 11 new prescriptions including allium, cassia twig, poria, and almonds. It was concluded that there were regularity of comparability in ancient prescriptions for treating chest pain. Approaching and developing medicine for the treatment of chest pain should be from the following 6 points. The priority choice of single drug was cassia twig, and etc. The priority choice of couplet medicines was licorice and poria cocos, etc. The priority choice of triangle medicines was ginger, pinellia, cassia twig, and etc. The combination of high correlation should be chosen in treating chest pain, such as cassia twig, peucedani radix-＋ginger, and etc. The core drugs are necessary. In the warming yang method, cassia twig is the core drug and ginger is the auxiliary drug, and etc. New prescription combination, such as allium, cassia twig, poria, almonds, and etc. should be applied.

关 键 词：胸痹 关联规则 复杂网络 熵方法 配伍规律 新药研发 

分 类 号：R2-03[医药卫生—中医学]