消瘀康胶囊联合颅内血肿微创清除术治疗高血压基底节区脑出血疗效及对血清h-FABP、8-iso-PGF2α、SF的影响  

Curative effect of Xiaoyukang capsule combined with intracranial hematoma minimally invasive surgery on hypertensive basal ganglia hemorrhage and the effects on serum h-FABP,8-iso-PGF2 alpha and SF

作　　者：张永兵[1] 程延娜[2] 

机构地区：[1]陕西省延安市人民医院,陕西延安716000 [2]延安大学附属医院,陕西延安716000

出　　处：《现代中西医结合杂志》2017年第25期2757-2760,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察消瘀康胶囊联合颅内血肿微创清除术治疗高血压基底节区脑出血的疗效及对血清心脏型脂肪酸结合蛋白(h-FABP)、8-表氧前列腺素(8-iso-PGF2α)及血清铁蛋白(SF)的影响。方法将109例高血压基底节区脑出血患者随机分为观察组55例和对照组54例,对照组给予颅内血肿微创清除术治疗,观察组在对照组基础上给予消瘀康胶囊治疗,2组均连续治疗2周。观察2组治疗前及治疗第7,14天的颅内血肿量、血肿周围水肿量、NIHSS评分、日常生活活动能力(ADL)的BI评分情况。检测2组治疗前及治疗第7,14天血清h-FABP、8-iso-PGF2α、SF水平。结果 2组治疗第7,14天颅内血肿量、血肿周围水肿量、NIHSS评分均显著降低(P均<0.05),且观察组第7、14天上述指标均低于对照组(P均<0.05);2组治疗前BI评分比较差异无统计学意义(P>0.05),观察组治疗第7,14天BI评分均优于对照组(P均<0.05);2组治疗第7,14天血清h-FABP、8-iso-PGF2α、SF水平均显著降低(P均<0.05),且观察组上述指标水平均低于对照组(P均<0.05)。结论颅内血肿微创清除术联合消瘀康胶囊能够显著改善高血压基底节区脑出血患者脑水肿及周围血肿量,促进神经功能及日常生活活动能力的恢复,其机制可能与抑制血清h-FABP、8-iso-PGF2α、SF水平有关。Objective It is to observe the effect of Xiaoyukang capsule combined with intracranial hematoma minimally in-vasive surges on hypertensive basal ganglia hemorrhage and the effects on serum heart fatty acid binding protein （h-FABP）, 8-table oxygen prostaglandin （8-iso-PGF2a） and serum ferritin （SF）. Methods 119 patients with hypertensive basal ganglia hemorrhage were randomly divided into observation group （55 cases） and control group （54 cases）,the control group was treated with intracranial hematoma minimally invasive surgery,while the observation group was treated with Xiaoyukang cap-sule on the basis of treatment in the control group for 2 weeks. The amount of intracranial hematoma, peripheral edema, NIHSS score and daily life activity （ ADL） were observed and the levels of h-FABP, 8-iso-PGF2a, SF were detected in the two groups before treatment and after 7 and 14 days ^treatment. Results After 7 ,14 days’ treatment, the volume of intracranial hemato-ma ,peripheral edema, NIHSS scores, the levels of serum h-FABP, 8-iso-PGF2a and SF were significantly decreased in both groups compared with those before treatment（P 〈0. 05） , and the levels of these indexes in observation group were significantly lower than those in control group （P 〈0. 05） . There was no statistically significant difference in pre-treatment BI between the two groups（P 〉 0. 05） , but after 7, 14 days’ treatment, BI scores in observation group were better than that in control group （P 〈 0. 05 ） . Conclusion Xiaoyukang capsule combined with intracranial hematoma minimally invasive surges can significant-ly improve brain edema and peripheral hematoma, promote the recovery of neural function and daily life activities ability in the patients with hypertensive basal ganglia hemorrhage, its mechanism may be related to inhibition of serum levels of h-FABP, 8- iso-PGF2a and SF.

关 键 词：消瘀康胶囊 颅内血肿清除术 高血压脑出血 心脏型脂肪酸结合蛋白 8-表氧前列腺素 血清铁蛋白 

分 类 号：R544.1[医药卫生—心血管疾病] R743.34[医药卫生—内科学]