丹归消肿膏外敷对大鼠急性软组织损伤的消肿止痛作用  

Effect of Dangui Xiaozhong ointment on acute soft tissue injury in rat models

作　　者：杨大伟[1] 宋雪[1] 罗宗键[2] 冷向阳[2] YANG Dawei SONG Xue LUO Zongjian LENG Xiangyang(Department of Orthopaedics, Southem District of Guang＇ anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 102600, China Department of Orthopaedics, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130021, China)

机构地区：[1]中国中医科学院广安门医院南区骨二科,北京102600 [2]长春中医药大学附属医院骨科,长春130021

出　　处：《长春中医药大学学报》2017年第4期536-538,共3页Journal of Changchun University of Chinese Medicine

基　　金：吉林省科技厅项目(20080919)

摘　　要：目的观察丹归消肿膏外敷对造模大鼠急性软组织损伤的消肿止痛作用。方法选取36只Wistar大鼠,随机分为模型组(A组)、辽源七厘散组(B组)、丹归消肿膏组(C组)。A组大鼠涂基质软膏,B组涂辽源七厘散,C组涂丹归消肿膏,2次/d,分别涂抹7 d后,观察角叉菜胶引起足肿胀的程度和对痛阈值的影响。结果注射0.8%角叉菜胶0.1 m L/只1、2、4、5、6 h后B、C组与A组比较,足肿胀程度明显降低(P<0.01,P<0.05);B、C组比较注射后足肿胀程度无明显变化。检测大鼠痛阈值的改变观察药物的镇痛作用,B、C组大鼠痛阈值高于A组(P<0.01,P<0.05),C组的大鼠痛阈值高于B组(P<0.01,P<0.05)。结论丹归消肿膏治疗大鼠急性软组织损伤能有效抑制足肿胀和明显镇痛,消肿止痛。Objective To observe the effect of external using Dangui Xiaozhong ointment in treating acute soft tissue injury（ASTI） in rat models. Methods 36 Wistar rats were randomly divided into model group（A）, Liaoyuan Qilisan group（B） and Dangui Xiaozhong ointment group（C）. Group A rats were coated with matrix ointment, B group was coated with Liaoyuan Qilisan and group C was treated with Dangui Xiaozhong ointment, 2 times/d. To observe the degree o f foot swelling caused by carrageenin and its influence on pain threshold after 7 days. Results There was difference reduce in foot swelling of B, C groups than A group at 1, 2, 4, 5, 6 hour（P〈0.01, P〈0.05）. B, C group after the injection of foot swelling had no obvious change. The analgesic effect of the drug was detected by detecting the change of the pain threshold in rats.B,C groups were higher than A group in pain threshold（P〈0.01, P〈0.05）. C groups were higher than B group in pain threshold（P〈0.01, P〈0.05）. Conclusion Dangui Xiaozhong ointment treatment of acute soft tissue injury in rats can effectively inhibit foot swelling and obvious analgesic effect, swelling and pain relief

关 键 词：丹归消肿膏 中药外敷 急性软组织损伤 

分 类 号：R285.5[医药卫生—中药学]