维生素D与2型糖尿病患者握力的相关性研究  

The relationship between vitamin D status and grip strength in type 2 diabetes mellitus patients

作　　者：刘国庆[1] 王蓓蓓[1] 陈新焰[1] 徐伟民[2] 赵连礼[1] 司文[1] LIU Guoqing WANG Beibei CHEN Xinyan XU Weimin ZHAO Lianli SI Wen(Department of Endocrinology, Shengli Oilfield Central Hospital, Dong Ying, Shandong 257000 Department of Anesthesia, Shengli Oilfield Central Hospital, Dong Ying, Shandong 257000, China)

机构地区：[1]胜利油田中心医院内分泌科,山东东营257000 [2]胜利油田中心医院麻醉科,山东东营257000

出　　处：《中国骨质疏松杂志》2017年第8期1049-1053,1062,共6页Chinese Journal of Osteoporosis

摘　　要：目的分析2型糖尿病患者的握力与维生素D的相关关系,探讨维生素D对握力的影响。方法对126名2型糖尿病患者及121名健康人群进行研究,测定体重指数、股骨颈的骨密度、25(OH)D_3水平,应用握力计测定双手握力。分析维生素D水平对握力的影响。结果与正常对照组相比较:2型糖尿病患者维生素D水平偏低[男:(12.45±6.93)ng/m L对(16.25±6.73)ng/m L;女:(10.67±6.23)ng/m L对(13.29±6.24)ng/m L,均P<0.05],握力低于正常对照组[男:(35.34±8.86)kg对(37.67±10.27)kg;女:(23.30±5.95)kg对(35.34±8.86)kg,均P<0.05],女性股骨颈密度低于对照组[(0.89±0.13)kg对(1.05±0.16)g/cm^2,P<0.05];(2)126名糖尿病患者平均年龄58.7±11.7岁,男女比例65:61,男女患者分别按照25(OH)D_3水平分为3组:严重缺乏组(<10 ng/m L);缺乏组(≥10 ng/m L而<20 ng/m L);不足组(≥20 ng/m L而<30 ng/m L)。男性患者中,与维生素D不足组相比较,严重缺乏组的骨密度降低,握力减少,差异具有统计学差异[(33.54±7.77)kg对(39.34±5.91)kg,P<0.05]。女性患者中,与维生素D不足组相比较,维生素D缺乏组、严重缺乏组的骨密度减低,握力降低[(18.03±5.32)kg对(22.68±6.78)kg、(28.10±0.07)kg,P均<0.05];(3)多元直线逐步回归分析显示2型糖尿病患者中25(OH)D_3与握力呈正相关(r=0.239,P=0.031),且独立于年龄、性别、股骨颈骨密度。结论 2型糖尿病患者维生素D水平同握力之间存在独立正相关。Objective To analyze the relationship between vitamin D status and grip strength in type 2 diabetes mellitus patients,and to investigate the effect of vitamin D on grip strength. Methods One hundred and twenty-six patients with type 2 diabetes were enrolled. All subjects were measured for body mass index（ BMI）,bone mineral density（ BMD） of the femoral neck and serum 25-hydroxyvitamin D（25（OH）D3） levels. Subjects were assessed for grip strength using a handgrip dynamometer. Linear regression analysis was used to determine the associations between vitamin D and grip strength. Results Compared with healthy controls,type 2 diabetes patients had lower 25-hydroxyvitamin D（25（OH）D3） levels（ male： 12. 45 ± 6. 93 ng/m L vs 16. 25 ±6. 73 ng/m L; female： 10. 67 ± 6. 23 ng/m L vs 13. 29 ± 6. 24 ng/m L,both P〈0. 05）,lower grip strength（ male： 35. 34 ± 8. 86 kg vs 37. 67 ± 10. 27 kg; female： 23. 30 ± 5. 95 ng/m L vs 35. 34 ± 8. 86 kg,both P〈0. 05）,and females patients also had lower femoral neck BMD（ 0. 89 ± 0. 13 g/cm^2 vs 1. 05 ± 0. 16 g/cm^2,P〈0. 05）. Sixty-five male and 61 female diabetic patients were included in this study,and the average age was 58. 65 ± 11. 67 years. According to the level of serum 25（OH）D3,the male and the female patients were divided into three groups： seriously deficient group（ 10 ng/m L）,deficient group（ ≥10 ng/m L but 20ng/m L） and insufficient group（ ≥20 ng/m L but 30 ng/m L）. In male patients,femoral neck BMD and grip strength in the seriously deficient group were lower than those of the insufficient group（ 33. 54 ± 7. 77 kg vs39. 34 ± 5. 91 kg,P〈0. 05）. In female patients,the femoral neck BMD and grip strength in the seriously deficient group and deficient group were lower than those of the insufficient group（ 18. 03 ± 5. 32 vs 22. 68 ± 6. 78 vs 28. 10 ± 0. 07 kg,P〈0. 05]. Multiple stepwise regression analysis showed that the level of 25（OH）D3 was positively correlated with the grip strength in

关 键 词：维生素D 糖尿病 2型 握力 

分 类 号：R589.9[医药卫生—内分泌]