强骨胶囊联合鹿瓜多肽注射液治疗老年原发性骨质疏松症的临床研究  

Clinical study on Qianggu Capsules combined with Cervus and Cucumis Polypeptide Injection in treatment of senile primary osteoporosis

作　　者：周瑞明[1] 管义红[2] 王全兵[1] 刘培超[1,1] ZHOU Rui-ming GUAN Yi-hong WAGN Quan-bing LIU Pei-chao(Department of Orthopaedics, the Affiliated People＇s Hospital of Hubei Medical College （Shiyan People＇s Hospital）, Shiyan 442000, China Department of Traditional Chinese Medicine, the Affiliated Taihe Hospital of Hubei Medical College, Shiyan 442000, China)

机构地区：[1]湖北医药学院附属人民医院(十堰市人民医院)骨科,湖北十堰442000 [2]湖北医药学院附属太和医院中医科,湖北十堰442000

出　　处：《现代药物与临床》2017年第7期1337-1340,共4页Drugs & Clinic

摘　　要：目的探讨强骨胶囊联合鹿瓜多肽注射液治疗老年原发性骨质疏松症的临床疗效。方法选取2016年3月—2017年3月湖北医药学院附属人民医院(十堰市人民医院)收治的老年原发性骨质疏松症患者102例,根据用药的差别分成对照组和治疗组,每组各51例。对照组静脉滴注鹿瓜多肽注射液,10 mL与5%葡萄糖溶液250 mL配伍,1次/d。治疗组在对照组基础上口服强骨胶囊,1粒/次,3次/d。两组患者均治疗4周后进行疗效评价。观察两组的临床疗效,比较两组治疗前后VAS评分、ODI评分、骨密度(BMD)和血清学相关指标的变化情况。结果治疗后,对照组和治疗组总有效率分别为80.39%、96.08%,两组比较差异具有统计学意义(P<0.05)。两组治疗后血清转化生长因子-β1(TGF-β1)、Ⅰ型原胶原N-端前肽(PINP)、骨钙素(BGP)、骨碱性磷酸酶(ALP)均显著升高,抗酒石酸酸性磷酸酶(TRACP)水平显著降低,同组治疗前后差异有统计学意义(P<0.05);治疗后,治疗组TGF-β1、PINP、BGP、ALP高于对照组,TRACP水平低于对照组,两组比较差异具有统计学意义(P<0.05)。结论强骨胶囊联合鹿瓜多肽治疗老年原发性骨质疏松症具有较好的临床疗效,可有效改善患者疼痛,增加BMD及改善骨代谢指标,具有一定的临床推广应用价值。Objective To investigate the clinical efficacy of Qianggu Capsules combined with Cervus and Cucumis Polypeptide Injection in treatment of senile primary osteoporosis. Methods Patients（102 cases） with senile primary osteoporosis in the Affiliated People＇s Hospital of Hubei Medical College（Shiyan People＇s Hospital） from March 2016 to March 2017 were divided into control（51 cases） and treatment（51 cases） groups based on different treatments. Patients in the control group were iv administered with Cervus and Cucumis Polypeptide Injection, 10 mL added into 5% glucose solution 250 mL, once daily. Patients in the treatment group were po administered with Qianggu Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of VAS score, ODI score, bone density（BMD） and blood related indicators in two groups before and after treatment were compared. Results After treatment, After treatment, the clinical efficacies in the control and treatment groups were 80.39% and 96.08%, respectively, and there was difference between two groups（P〈0.05）. After treatment, TGF-β1, PINP, BGP, and ALP were significantly increased, but TRACP in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, TGF-β1, PINP, BGP, and ALP in the treatment group were higher than those in the control group, but TRACP in the treatment group were significantly lower than that in the control group, and the difference was statistically significant between two groups（P〈0.05）. Conclusion Qianggu Capsules combined with Cervus and Cucumis Polypeptide Injection has clinical curative effect in treatment of senile primary osteoporosis, and can effectively improve pain situation, also can increase BMD and improve bone metabolism indexes, which has a certain clinical application value.

关 键 词：强骨胶囊 鹿瓜多肽注射液 原发性骨质疏松症 VAS评分 ODI评分 骨密度 

分 类 号：R982[医药卫生—药品]