Two pairs of chlorine-containing phenylpropanoid enantiomers from Acorus tatarinowii  

作　　者：Yuan-Yuan Lu Xue-Peng Gong Yong-Bo Xue Hu-Cheng Zhu Xiao-Nian Li Lin-Zhen Hu Jian-Kun Guan Jin-Wen Zhang Guang Du Yong-Hui Zhang 

机构地区：[1]Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology [2]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology [3]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences [4]College of Life Science, Hubei University

出　　处：《Chinese Chemical Letters》2017年第7期1460-1464,共5页中国化学快报（英文版）

基　　金：financially supported by the Program for New Century Excellent Talents in University, State Education Ministry of China (No. NCET2008-0224);the National Natural Science Foundation of China (Nos. 31370372, 81573316, 31570361, 31200258)

摘　　要：Two pairs of chlorine-containing phenylpropanoid enantiomers（1a/1b and 2a/2b） were isolated from the rhizomes of Acorus tatarinowii. Interestingly, these optical isomers（1a/1b and 2a/2b） were co-existed in the same plant, which were characterized as the first halogen-containing natural products from the genus Acorus. Their structures and absolute configurations were elucidated by a combination of spectroscopic analysis and a single-crystal X-ray diffraction, assisted by a modified Mosher＇s method. The phenylpropanoid isomers（1a/1b and 2a/2b） were evaluated for their antioxidant activities using DPPH assay and cytotoxic activities against five human cancer cell lines.Two pairs of chlorine-containing phenylpropanoid enantiomers（1a/1b and 2a/2b） were isolated from the rhizomes of Acorus tatarinowii. Interestingly, these optical isomers（1a/1b and 2a/2b） were co-existed in the same plant, which were characterized as the first halogen-containing natural products from the genus Acorus. Their structures and absolute configurations were elucidated by a combination of spectroscopic analysis and a single-crystal X-ray diffraction, assisted by a modified Mosher＇s method. The phenylpropanoid isomers（1a/1b and 2a/2b） were evaluated for their antioxidant activities using DPPH assay and cytotoxic activities against five human cancer cell lines.

关 键 词：Acorus tatarinowii Chlorine-containing phenylpropanoid Enantiomers Antioxidant activity Cytotoxicity 

分 类 号：TQ460.1[化学工程—制药化工]