Uncinatic acids A-C,three new carboxylated flavonoids from Selaginella uncinata  

作　　者：Rui Liu Hui Zou Ping-Sheng Xu Zhen-Xing Zou Jing Li Fei Cheng Rui-Huan Liu Gan Zhou Kang-Ping Xu Gui-Shan Tan 

机构地区：[1]Xiangya Hospital of Central South University,Changsha 410008,China [2]Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China

出　　处：《Chinese Chemical Letters》2017年第7期1465-1468,共4页中国化学快报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(No.31370370);Key Project of Science and Technology of Hunan Province,China(Nos.2014SK2002 and 2013SK5077);Key Project of Application Technology Research and Development of Haikou(No.2015-039);Social Development and Technology Specific Program of Hainan Province(No.SF201419)

摘　　要：Three new carboxylated flavonoids, uncinatic acids A-C（1–3）, were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including1 D, 2D NMR experiments and HR-ESIMS techniques. All of them share the carboxylation structural characteristic. Compounds 1 and 2 belong to novel naturally occuring furanoflavonoids which is firstly reported in genus Selaginella. Such furanoflavonoids with dicarboxylic acid structrure have never been discovered before. In addition, the isolates were tested for their cytotoxicity against A549 and BGC-823 cell lines in vitro.Three new carboxylated flavonoids, uncinatic acids A-C（1–3）, were isolated from the whole herb of Selaginella uncinata. Their structures were established on the basis of extensive NMR analysis including1 D, 2D NMR experiments and HR-ESIMS techniques. All of them share the carboxylation structural characteristic. Compounds 1 and 2 belong to novel naturally occuring furanoflavonoids which is firstly reported in genus Selaginella. Such furanoflavonoids with dicarboxylic acid structrure have never been discovered before. In addition, the isolates were tested for their cytotoxicity against A549 and BGC-823 cell lines in vitro.

关 键 词：Selaginella uncinata Selaginella Uncinatic acids A-C Carboxylated flavonoids Furanoflavonoids Anticancer Cytotoxicity 

分 类 号：TQ464[化学工程—制药化工]