Facile synthesis of CF_3-substituted dienamides via one-pot tandem reactions  

作　　者：Zhe-Zhe Yuan Xiang-Wen Kong Li-Hua Liu Hui-Xia Zhu Hua Xiao 

机构地区：[1]Department of Pharmaceutical Engineering, Hefei University of Technology [2]Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

出　　处：《Chinese Chemical Letters》2017年第7期1469-1472,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 21302034);the Fundamental Research Funds for the Central Universities (No. 2013HGQC0028)

摘　　要：A one-pot reaction sequence of sequential phosphine-promoted tandem annulations of aryl trifluoromethyl ketones and MBH（Morita-Baylis-Hillman） carbonates and DBU-mediated aminolysis was developed. This method provides a step-economical approach to trifluoromethylated dienamides with diverse structural complexity from readily available starting materials in moderate yields.A one-pot reaction sequence of sequential phosphine-promoted tandem annulations of aryl trifluoromethyl ketones and MBH（Morita-Baylis-Hillman） carbonates and DBU-mediated aminolysis was developed. This method provides a step-economical approach to trifluoromethylated dienamides with diverse structural complexity from readily available starting materials in moderate yields.

关 键 词：Dienamides Aminolysis Butenolide Phosphine catalysis One-pot 

分 类 号：O623.626[理学—有机化学]