Protein corona in vivo: dynamic complement proteins-mediated opsonization and immune modulation  

作　　者：Rong Cai Chunying Chen 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China

出　　处：《Science Bulletin》2017年第14期976-977,共2页科学通报（英文版）

基　　金：supported by the National Basic Research Program of China(2016YFA0201600);the Chinese Academy of Sciences Key Research Program for Frontier Sciences(QYZDJ-SSSLH022),the Chinese Academy of Sciences Interdisciplinary Innovation Team;the National Science Fund for Distinguished Young Scholars(11425520)

摘　　要：It has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer,known as‘‘protein corona',which directly interacts with and is recognized by cells.These interactions play a critical role in affecting nanoparticle biological properties,including biodistribution[1],pathophysiology[2],and therapeutic efficacy[3].The compositions of protein corona undergo dynamic exchange in vivo and areIt has been well-established that blood biomolecules deposit on the surface of nanoparticles forming a protein rich layer, known as ＂protein corona＂, which directly interacts with and is recognized by cells. These interactions play a critical role in affecting nanopar- ticle biological properties, including biodistribution [1], patho- physiology [2], and therapeutic efficacy [3].

关 键 词：蛋白质 免疫调节 调理作用 介导 补体 啤酒 体内 纳米颗粒 

分 类 号：R392[医药卫生—免疫学]