中药破壁饮片治肠癌化疗后造血抑制临床研究  

Clinical Observation of Chinese Medicinal Cell Wall-Broken Decoction Pieces for Hematopoietic Inhibition after Chemotherapy of Colorectal Cancer

作　　者：林伟波[1] 周岱翰[2] 

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]广州中医药大学肿瘤研究所,广东广州510405

出　　处：《新中医》2017年第8期110-113,共4页New Chinese Medicine

摘　　要：目的 :观察参芪固本方破壁饮片治疗大肠癌化疗后的造血功能改善情况及量效关系。方法:将大肠癌化疗(行FOLFOX或FOLFIRI方案化疗)后出现造血抑制的患者60例按入院顺序均分为3组,研究组予参芪固本方破壁饮片,每次16 g,每天2次,冲服。对照A组予参芪固本方传统饮片煎剂,每天1剂,每剂120 g,煎成200 m L,分2次服。对照B组予中成药贞芪扶正颗粒,每次5 g,每天2次,冲服。均治疗28天为1疗程,共治疗2疗程。结果:3组神疲乏力、食欲减退、腰脊酸痛、自汗盗汗的有效率分别为(85.0%、70.0%、60.0%),(75.0%、80.0%、55.0%),(80.0%、85.0%、50.0%),(80.0%、70.0%、45.0%)。3组间食欲减退、腰脊酸痛疗效比较,差异均有统计学意义(P<0.05);研究组及对照组A组食欲减退、腰脊酸痛疗效分别与对照组B组比较,差异均有统计学意义(P<0.05)。3组血白细胞(WBC)、血红蛋白(Hb)治疗前后组内分别比较,差异均有统计学意义(P<0.05);研究组中性粒细胞(NEU)治疗前后比较,差异有统计学意义(P<0.05)。3组组间肿瘤缓解稳定率、Karnofsky评分有效率比较,差异均无统计学意义(P>0.05)。3组肝功能指标天门冬氨酸氨基转移酶(AST)、丙氨酸基转移酶(ALT)分别与治疗前比较,差异均有统计学意义(P<0.05)。3组肾功能指标血尿素氮(BUN)、血清肌酐(SCr)分别与治疗前比较,差异均无统计学意义(P>0.05),3组BUN、SCr间比较,差异均无统计学意义(P>0.05)。结论:3组皆可在不同程度上改善大肠癌化疗后出现造血抑制以脾肾亏虚为主的部分症状,肝功能有所改善,可能有减毒作用。低剂量的参芪固本方破壁饮片与参芪固本方传统饮片疗效相当,提示有增效作用。3组均可在临床上改善大肠癌化疗后造血功能抑制情况。Objective. To observe improvement of hematopoietic function and dose-effect relationship of cell wall-broken decoction pieces of Shen qi guben recipe for hematopoietic inhibition after chemotherapy of colorectal cancer. Methods： Selected 60 patients with hematopoietic inhibition after chemotherapy of colorectal cancer, which were given FOLFOX or FOLFIRI into three groups according to their order of hospitalization randomly. The study group was given cell wall-broken decoction pieces of Shenqi guben recipe, 16 g/ time, twice a day, infused with water. The control group A was given traditional decoction pieces of Shen qi guben recipe once a day with 120 g, to be decocted in water of 200 mL which should be took two times. The control group B was given Chinese patent medicine Zhenqi fuzheng granule, 5g/time, twice a day, infused with water. Treatment of the three groups all lasted for two courses. One course lasted for 28 days. Results： The effective rate of lethargy, loss of appetite, aching in back, spontaneous sweat and night sweat of the three group were 85.0%, 70.0%, 60.0% and 75.0%, 80.0%, 55.0% and 80.0%, 85.0%, 50.0% and 80.0%, 70.0%, 45.0% respectively, differences of curative effect of loss of appetite and aching in back among the three groups being significant （P 〈0.05）~ Compared curative effect of loss of appetite and aching in the study group and the control group A with those in the control group B, differences were significant（P〈 0.05）. Compared Hemoglobin （Hb） and White blood cell of the three groups with those before treatment, differences were significant（P 〈 0.05）. After treatment, compared NEU of the study group with that before treatment, difference was significant （P〈0.05）. Compared stable rate of tumor remission and Karnofsky score of the three group, differences all had no significance （P 〉 0.05）. Compared liver function indexes AST and ALT of the three groups with those before treatment, differences were significant（P 〈 0.05）. Compared renal functio

关 键 词：中药破壁饮片 参芪固本方 造血抑制 血红蛋白(Hb) 血白细胞(WBC) 肝功能 

分 类 号：R283.6[医药卫生—中药学]