中药剂量递减方案降低慢性功能性便秘复发率临床观察  

Lowering the Recurrence Rate of CFC Through a Protocol of Decreased Progressively TCM Dosage：Clinical Observation

作　　者：余胜[1] 程德华[1] 余晓琪[1] 

机构地区：[1]安徽医科大学第一附属医院中医科,安徽合肥230000

出　　处：《中国肛肠病杂志》2017年第6期33-35,共3页Chinese Journal of Coloproctology

摘　　要：为观察中药剂量递减式方案降低慢性功能性便秘复发率的临床疗效,将2014年5月至2017年1月,安徽医科大学第一附属医院中医科收治的 90例慢性功能性便秘患者,随机分为对照组、观察1组、观察2组,每组各30例.对照组使用双歧杆菌三联活菌胶囊加聚乙二醇4000散剂方案,观察1组使用传统中药方案,观察2组亦使用传统中药方案,但方法采用递减式（2周后剂量递减,再2周后剂量再递减）.观察和评价各组患者用药前后便秘情况和临床评分;观察各组患者停药后2周及6个月的总有效率.结果显示, 停药后2周的各组便秘临床评分与用药前相比,差异有统计学意义（ P〈0.05）;观察2组停药后6个月与对照组及观察1组相比,差异亦有统计学意义（ P〈0.05）. 观察2组在停药2周后的总有效率,与对照组及观察1组比较,差异无统计学意义（P〉0.05）.观察2组在停药6个月后的总有效率为76.7%（23/30）,与对照组的40.0%（12/30）及观察1组的50.0%（15/30）相比较,差异有统计学意义 （P〈0.05）. 结果表明,采用中药剂量递减式方案治疗慢性功能性便秘能够降低患者远期复发率.This study was to observe the clinical effect of a protocols of decreased progressively TCM （tra- ditional Chinese medicine） for lowering the recurrence rate of CFC （chronic functional constipation）, ran- domly divided 90 cases of CFC who were admitted and treated in author＇s department into control group, observation group Ⅰ and group Ⅱ, 30 eases for each; performed on the control group a protocol of Bifidobacterium triplet vaccine capsule （live） plus macrogol 4000 powder, on group Ⅰ routine TCM proto- cols, on group Ⅱ also routine TCM protocols merely at ＂decrease progressively＂ pattern （i.e after 2 weeks,dosage decreasd progressively, continuously 2 weeks then once more decreased progressively）; ob- served and evaluated their constipation condition at pre- and post-medication, as well as relevant score clin- ically, again observed the total effective rate at 2 weeks and at 6 months after withdrawal in every group. As results, compared with pre-medication the clinical score on constipation condition of all groups at 2 weeks after withdrawal had statistical difference （ P 〈0.05）; compared with control group and group Ⅰ group Ⅱ at 6 months after withdrawal also had statistical difference （ P 〈0.05）, but its total effective rate just had no statistical difference （ P 〉0.05）; however at 6 months after withdrawal just had statistical difference [（76.7% （23/30） vs 40.0%（12/30） and 50.0% （15/30）] ,there was statistical difference （ P 〈 0.05）. Results show that above-mentioned protocols of decreased progressively dosage can lower the long- term recurrence rate of CFC patients.

关 键 词：慢性功能性便秘 中药 剂量递减 复发率 

分 类 号：R442.2[医药卫生—诊断学]