间充质干细胞在组织工程气管中的研究进展  

Current progress of mesenchymal stem cells in tissue engineering trachea

作　　者：单一波 范懿魏 史宏灿 王尧 

机构地区：[1]扬州大学临床医学院、江苏省中西医结合老年病防治重点实验室、扬州大学转化医学中心,225001

出　　处：《国际生物医学工程杂志》2017年第3期211-215,共5页International Journal of Biomedical Engineering

基　　金：国家自然科学基金面上项目（81170014,81370118）;扬州大学“高端人才支持计划”（201431）

摘　　要：组织工程学通过细胞或组织重建，修复缺损组织并保留其生物功能，成为气管替代治疗的新途径。种子细胞、生长因子及气管支架材料是组织工程气管的三大要素，学者们一直在寻求理想的种子细胞。间充质干细胞（MSCs）是一种具有高度自我更新能力和多向分化潜能的干细胞，广泛分布于骨髓、脐带、脂肪组织、心肌组织、大脑、肌肉和皮肤等，可向骨、软骨、脂肪、神经等多种细胞定向分化。MSCs具有增殖能力强、分化范围广、免疫调节等功能特点，能够修复损伤的组织，有望成为应用于组织工程气管的理想种子细胞。旨在对MSCs在组织工程气管中的应用作一综述。Tissue engineering can regenerate damaged tissues and restore the biological functions by cell or tissue reconstruction, and is becoming a promising method for trachea replacement. Seed ceils, cell growth factors and tracheal scaffolds are the three major elements of tissue engineering trachea, as a result researchers have paid a lot of attention to find ideal seed cells. Mesenchymal stem cells （MSCs） are a kind of stem ceils with high self-renewal ability and multi-directional differentiation potential. MSCs are widely distributed in bone marrow, umbilical cord, adipose tissue, myocardial tissue, brain, muscle and skin, and can differentiate into a variety of cells, including osteocytes, ehondrocytes, adipocytes and neurocytes. MSCs have the characteristics of high proliferation ability, wide differentiation range and immunomodulatory function, which can be used to repair damaged tissue. These advantages make the MSCs an ideal candidate of seed cells for tissue engineering trachea. This review mainly summarized the application of MSCs in tissue engineering trachea.

关 键 词：组织工程气管 种子细胞 间充质干细胞 

分 类 号：R318[医药卫生—生物医学工程]