PHB Associates with HIRA Complex to Control an EpigeneticMetabolic Circuit in Human ESCs  

作　　者：JIN Ying 

机构地区：[1]Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine

出　　处：《Bulletin of the Chinese Academy of Sciences》2017年第2期105-105,共1页中国科学院院刊（英文版）

基　　金：supported by grants of the Strategic Priority Research Program of CAS(XDA01010102 and XDB19020100);the Ministry of Science and Technology of China(2016YFA0100100 and 2013CB966801);the National Natural Science Foundation of China(91419309)

摘　　要：It is well known that embryonic stem cells can self-renewal unlimitedly and differentiate into all cell types of an organism in vitro,having broad applications for future organ regeneration and cell replacement therapy.However,there are still many questions about the molecular regulation ofIt is well known that embryonic stein cells can self-renewal unlimitedly and differentiate into all .cell types of an organism in vitro, having broad applications for future organ regeneration and cell replacement therapy. However, there are still many questions about the molecular regulation of self-renewal and pluripotency in hESCs. Therefore, it is important to study the mechanism by which hESCs maintain their own characteristics.

关 键 词：人类胚胎干细胞 表观遗传 PHB 复合物 电路 代谢 控制 自我更新 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]