育龄妇女孕前接种麻疹疫苗时间对8月龄内婴儿麻疹抗体水平效果分析  

Effect of the time of measles vaccination before pregnancy in women of childbearing age on the measles antibody levels of their infants aged within 8 months

作　　者：王叶子 郑坚荣 林苑梅 吴晓冰 梁赤波 刘赛 朱咏梅 温世贤 

机构地区：[1]东莞市长安镇社区卫生服务中心,广东东莞523880

出　　处：《实用预防医学》2017年第9期1075-1078,共4页Practical Preventive Medicine

基　　金：东莞市医疗卫生科技计划一般项目(2015105101241)

摘　　要：目的探讨育龄妇女孕前接种麻疹疫苗(MV)的时机对8月龄内婴儿麻疹抗体水平的影响。方法选取2013年1月-2015年5月在东莞市长安医院和长安镇社区卫生服务中心进行婚前检查的976名育龄妇女为观察对象,根据孕前接种MV时间的不同,分为三组,Ⅰ组(孕前3~6个月接种)、Ⅱ组(孕前7~12个月接种)、Ⅲ组(孕前>12个月接种),孕妇于接种前、接种后一个月、分娩时采集血清,分娩时采集脐带血,测定麻疹IgG抗体水平,分析三组孕妇接种前、接种后一月麻疹IgG抗体水平、麻疹IgG抗体阳性率及麻疹保护性抗体阳性率的变化和组间差异及母婴麻疹IgG抗体阳性率、保护性抗体阳性率及抗体滴度的相关性。结果项目成功收集符合条件并成功分娩的630例孕妇的相关资料,Ⅰ组、Ⅱ组和Ⅲ组各210例。三组间孕妇接种前、接种后一月的麻疹IgG抗体水平、麻疹IgG抗体阳性率及麻疹保护性抗体阳性率的比较差异无统计学意义(P>0.05)。各组接种后一月的麻疹IgG抗体水平、麻疹IgG抗体阳性率及麻疹保护性抗体阳性率均较接种前显著升高(P<0.05)。分娩时三组母亲及所产新生儿麻疹IgG抗体阳性率比较差异有统计学意义(P<0.05),两两比较发现,Ⅰ、Ⅱ组母亲及所产新生儿麻疹IgG抗体阳性率及麻疹保护性抗体阳性率差异均显著高于Ⅲ组(P<0.017)。新生儿抗体水平随母亲抗体水平升高而升高,两者之间呈正相关(Pearson相关系数=0.999,P=0.020)。结论孕前3~12个月内育龄妇女接种MV,能明显提高婴儿麻疹抗体水平。Objective To explore the influence of the time of measles vaccination before gregnancy in women of childbearing age on the measles antibody levels of their infants under 8 month of age. Methods A total of 976 women of childbearing age who received premarital health check in Chang’an Hospital of Dongguan City and Community Health Service Center of Chang’an County from January 2013 to May 2015 were selected to serve as the observation objects. According to measles vaccination at the different time points, all the women were divided into the group I （vaccinated 3-6 months before pregnancy）, the group II （vaccinated 7-12 months before pregnancy） and the group III （vaccinated 〉12 months before pregnancy）. Serum samples of the pregnant women were collected before vaccination, one month after vaccination and during childbirth, and umbilical cord blood samples also collected in the process of giving birth. The IgG antibody levels of measles were determined. We analyzed and compared the changes and differences in the IgG antibody levels of measles, the positive rates of measles IgG antibody and the positive rates of protective antibody before vaccination and one month after vaccination among the three groups. We also analyzed the correlation between the positive rate of measles IgG, the positive rate of protective antibody and the geometric mean concentration （GMC） in the mothers and their infants. Results We collected the data about 630 pregnant women who were eligible and had successful delivery from the three groups （each n=210）. No statistically significant differences were found in the IgG antibody levels of measles, the positive rates of measles IgG antibody and the positive rates of protective antibody before vaccination and one month after vaccination among pregnant women in the three groups （all P〉0.05）. The IgG antibody level of measles, the positive rate of measles IgG antibody and the positive rate of protective antibody one month after vaccination in each group were all increas

关 键 词：育龄妇女 接种 麻疹疫苗 抗体 婴儿 

分 类 号：R186[医药卫生—流行病学]